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5-hydroxytryptamine receptor 2C

Summary

Gene Symbol

Htr2c

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25187

PubChem

25187

Alliance of Genome Resources

RGD:2848

Annotation

Keyword

3D-structure
Behavior
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q62842
P08909	5-hydroxytryptamine receptor 1C Serotonin receptor 2C

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	PMID
behavioral fear response	ISS
behavioral fear response	ISO
intracellular calcium ion homeostasis	ISO
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	9153397
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

phospholipase D-activating G protein-coupled receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

serotonin receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cGMP-mediated signaling

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

nonassociative learning [inference]

sensitization

behavior [inference]

behavioral defense response [inference]

behavioral fear response

learning or memory [inference]

learning [inference]

nonassociative learning [inference]

sensitization

adult behavior [inference]

behavioral response to nicotine

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration

animal organ development [inference]

animal organ regeneration

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phosphate metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of amine metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

regulation of secretion [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of gamma-aminobutyric acid secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amine transport [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of amine transport [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amine transport [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amine transport [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

phospholipase D-activating G protein-coupled receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

serotonin receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cGMP-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phosphate metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of appetite

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IBA
plasma membrane	IEA
external side of plasma membrane	IDA	1373499

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

G protein-coupled serotonin receptor complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
Gq/11-coupled serotonin receptor activity	ISS
Gq/11-coupled serotonin receptor activity	ISO
G protein-coupled serotonin receptor activity	ISO
G protein-coupled serotonin receptor activity	IMP	15663485
G protein-coupled serotonin receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

organic cyclic compound binding [inference]

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

Gq/11-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hydrolase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
S-formylglutathione hydrolase activity
formaldehyde catabolic process
hydrolase activity, acting on ester bonds
hydrolase activity

Displaying **all 3** entries
InterPro
Alpha/Beta hydrolase fold
Esterase-like
S-formylglutathione hydrolase

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cell surface	PMID:15663485

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:1470	major depressive disorder	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:2030	anxiety disorder	Alliance of Genome Resources
DOID:303	substance-related disorder	Alliance of Genome Resources
DOID:809	cocaine abuse	Alliance of Genome Resources
DOID:9975	cocaine dependence	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 49 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3356	FB:FBgn0261929
Drosophila melanogaster	3357	FB:FBgn0261929
Homo sapiens	3358	Xenbase:XB-GENE-967634	HUMAN101920
Drosophila melanogaster	15558	FB:FBgn0261929
Drosophila melanogaster	15559	FB:FBgn0261929
Mus musculus	15560	Xenbase:XB-GENE-967634	MOUSE64537
Xenopus tropicalis	25187	Xenbase:XB-GENE-967634
Drosophila melanogaster	29581	FB:FBgn0261929
Drosophila melanogaster	29595	FB:FBgn0261929
Canis lupus familiaris	450240		CANLF20073

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements