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Guidelines

MIRAGE

interleukin 2 receptor subunit beta

Summary

Gene Symbol

IL2RB

Organism

Homo sapiens (human)

External Links

NCBI Gene

3560

PubChem

3560

Alliance of Genome Resources

HGNC:6009

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
Disulfide bond
Glycoprotein
Host-virus interaction
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P14784	High affinity IL-2 receptor subunit beta Interleukin-15 receptor subunit beta p70-75

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
protein-containing complex assembly	TAS	2467293

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
endosome	TAS
cytosol	TAS
plasma membrane	TAS
plasma membrane	IC	7973659
plasma membrane	IMP	31040184 31040185

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

interleukin-2 receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

interleukin-2 receptor complex

cellular anatomical entity [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
interleukin-2 binding	ISS
interleukin-2 binding	IMP	2467293 31040184 31040185
interleukin-2 binding	IBA
interleukin-15 receptor activity	IDA	15123770

GO Hierarchy

molecular function

binding [inference]

protein binding

growth factor binding [inference]

interleukin-2 binding

cytokine binding [inference]

interleukin-2 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

coreceptor activity

immune receptor activity [inference]

cytokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Interleukin-2 receptor subunit beta

Functional Category

C: Energy production and conversion
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cytokine-mediated signaling pathway
interleukin-2 binding

Displaying **all 5** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Interleukin-2 receptor subunit beta, N-terminal
Short hematopoietin receptor, family 1, conserved site

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0111997	immunodeficiency 63	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:437	myasthenia gravis	Alliance of Genome Resources
DOID:9146	visceral leishmaniasis	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ictidomys tridecemlineatus	101974742		ICTTR14208
Chinchilla lanigera	102028734		CHILA04490
Macaca fascicularis	102138714		MACFA00435
Erinaceus europaeus	103110233		ERIEU04773
Chlorocebus sabaeus	103223268		CHLSB07275
Ursus maritimus	103676409		URSMA18634
Nannospalax galili	103748643		NANGA12725
Serinus canaria	103813230		SERCA05747
Rhinopithecus roxellana	104682498		RHIRO04156
Pteropus vampyrus	105311493		PTEVA07226

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Last updated: August 4, 2025