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apolipoprotein M

Summary

Gene Symbol

APOM

Organism

Homo sapiens (human)

External Links

NCBI Gene

55937

PubChem

55937

Alliance of Genome Resources

HGNC:13916

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disulfide bond
Glycoprotein
HDL
Lipid transport
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A1U9X793
O95445	Protein G3a

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 15 in total

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GO Term	Evidence Code	PMID
negative regulation of plasma lipoprotein oxidation	IDA	16682745 22204862
lipoprotein metabolic process	IEA
cholesterol homeostasis	IC	15793583
reverse cholesterol transport	ISS	15793583
cellular oxidant detoxification	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

lipoprotein metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

lipoprotein metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

lipoprotein metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

lipoprotein metabolic process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

cellular detoxification [inference]

cellular oxidant detoxification

multicellular organismal process [inference]

plasma lipoprotein particle clearance [inference]

high-density lipoprotein particle clearance

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport

sterol transport [inference]

cholesterol transport [inference]

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of plasma lipoprotein oxidation

negative regulation of multicellular organismal process [inference]

negative regulation of plasma lipoprotein oxidation

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of plasma lipoprotein oxidation

regulation of cellular component organization [inference]

regulation of plasma lipoprotein oxidation [inference]

negative regulation of plasma lipoprotein oxidation

negative regulation of cellular component organization [inference]

negative regulation of plasma lipoprotein oxidation

regulation of multicellular organismal process [inference]

regulation of plasma lipoprotein oxidation [inference]

negative regulation of plasma lipoprotein oxidation

negative regulation of multicellular organismal process [inference]

negative regulation of plasma lipoprotein oxidation

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
very-low-density lipoprotein particle	IDA	17154273
very-low-density lipoprotein particle	IBA
low-density lipoprotein particle	IDA	16682745
low-density lipoprotein particle	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

low-density lipoprotein particle

high-density lipoprotein particle

triglyceride-rich plasma lipoprotein particle [inference]

very-low-density lipoprotein particle

cellular anatomical entity [inference]

extracellular region

Displaying **all 5** entries
GO Term	Evidence Code	PMID
lipid transporter activity	IDA	16682745
lipid transporter activity	IBA
phospholipid binding	IDA	22204862
phospholipid binding	IBA
antioxidant activity	IDA	22204862

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity

binding [inference]

lipid binding [inference]

phospholipid binding

antioxidant activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

apolipoprotein m

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
cholesterol efflux
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
high-density lipoprotein particle remodeling
lipid transport
lipid transporter activity
phospholipid binding

Displaying **all 2** entries
InterPro
Apolipoprotein M
Calycin

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 62 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	55937	Xenbase:XB-GENE-479083
Mus musculus	55938		MOUSE20648
Pan troglodytes	462561		PANTR37702
Canis lupus familiaris	474843		CANLF02550
Sus scrofa	692188		PIGXX31159
Macaca mulatta	715848		MACMU33764
Monodelphis domestica	100025006		MONDO10962
Equus caballus	100050362		HORSE19403
Pongo abelii	100173132		PONAB31232
Oryctolagus cuniculus	100350574		RABIT02193

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OrthoDB (Group)

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Acknowledgements