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Guidelines

MIRAGE

prostaglandin D2 receptor

Summary

Gene Symbol

PTGDR

Organism

Homo sapiens (human)

External Links

NCBI Gene

5729

PubChem

5729

Alliance of Genome Resources

HGNC:9591

Annotation

Keyword

Alternative splicing
Asthma
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Mast cell degranulation
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13258	Prostanoid DP receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
mast cell degranulation	IEA
adenosine metabolic process	IEA
cellular response to prostaglandin D stimulus	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte degranulation [inference]

mast cell degranulation

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

organic substance metabolic process [inference]

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

adenosine metabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

reproductive process [inference]

developmental process involved in reproduction [inference]

sex determination [inference]

male sex determination

multicellular organismal process [inference]

sleep

developmental process [inference]

developmental process involved in reproduction [inference]

sex determination [inference]

male sex determination

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to prostaglandin [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to prostaglandin [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

response to lipid [inference]

response to prostaglandin [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

response to alcohol [inference]

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

response to ketone [inference]

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

response to ketone [inference]

response to prostaglandin D [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to lipid [inference]

cellular response to prostaglandin stimulus [inference]

cellular response to prostaglandin D stimulus

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to prostaglandin D stimulus

cellular response to ketone [inference]

cellular response to prostaglandin D stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

establishment of localization in cell [inference]

leukocyte degranulation [inference]

mast cell degranulation

establishment of organelle localization [inference]

mast cell degranulation

organelle localization [inference]

establishment of organelle localization [inference]

mast cell degranulation

vacuolar localization [inference]

lysosome localization [inference]

mast cell degranulation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	20959461
plasma membrane	IBA
membrane	NAS	7642548

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
prostaglandin J receptor activity	IEA
prostaglandin D receptor activity	NAS	7642548
prostaglandin D receptor activity	IBA
protein binding	IPI	20959461 32334026

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

icosanoid receptor activity [inference]

prostanoid receptor activity [inference]

prostaglandin receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

prostaglandin e2 receptor ep3 subtype

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
inflammatory response
positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Prostanoid receptor

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2841	asthma	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 70** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Microcebus murinus	105867693		MICMU09026
Dipodomys ordii	105982619		DIPOR05259
Equus asinus asinus	106839487		EQUAS15251
Rhinopithecus bieti	108513698		RHIBE05232
Vulpes vulpes	112921432		VULVU14272
Bos indicus x Bos taurus	113900213		BOBOX22893
Taeniopygia guttata	115495324		TAEGU25310
Strigops habroptila	115607497		STRHB09325
Corvus moneduloides	116446053		CORMO23609
Rhinolophus ferrumequinum	117023617		RHIFE30922

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Last updated: August 4, 2025