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gamma-aminobutyric acid type B receptor subunit 2

Summary

Gene Symbol

GABBR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9568

PubChem

9568

Alliance of Genome Resources

HGNC:4507

Annotation

Keyword

3D-structure
Cell membrane
Coiled coil
Direct protein sequencing
Disease variant
Disulfide bond
Epilepsy
G-protein coupled receptor
Glycoprotein
Intellectual disability
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O75899	G-protein coupled receptor 51 HG20
H9NIL8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	TAS	9872316
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	987231
negative regulation of adenylate cyclase activity	TAS	10328880
gamma-aminobutyric acid signaling pathway	IDA	987231 9872316
gamma-aminobutyric acid signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, GABAergic

neuron-glial cell signaling

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, GABAergic

neuron-glial cell signaling

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of cyclase activity [inference]

negative regulation of adenylate cyclase activity

negative regulation of lyase activity [inference]

negative regulation of adenylate cyclase activity

regulation of catalytic activity [inference]

regulation of cyclase activity [inference]

negative regulation of cyclase activity [inference]

negative regulation of adenylate cyclase activity

regulation of adenylate cyclase activity [inference]

negative regulation of adenylate cyclase activity

negative regulation of catalytic activity [inference]

negative regulation of cyclase activity [inference]

negative regulation of adenylate cyclase activity

negative regulation of lyase activity [inference]

negative regulation of adenylate cyclase activity

regulation of lyase activity [inference]

regulation of adenylate cyclase activity [inference]

negative regulation of adenylate cyclase activity

negative regulation of lyase activity [inference]

negative regulation of adenylate cyclase activity

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
plasma membrane	TAS
plasma membrane	IDA	15304491 9872316
G protein-coupled receptor heterodimeric complex	IBA
G protein-coupled receptor heterodimeric complex	IPI	9872316

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex [inference]

G protein-coupled receptor dimeric complex [inference]

GABA receptor complex

G protein-coupled GABA receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex [inference]

G protein-coupled receptor dimeric complex [inference]

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying **all 4** entries
GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IBA
G protein-coupled GABA receptor activity	IDA	9872316
protein binding	IPI	16724110 24305054 24658140 32555460 32580208 32581365 37207277
protein heterodimerization activity	IPI	15304491

GO Hierarchy

molecular function

binding [inference]

protein binding

protein dimerization activity [inference]

protein heterodimerization activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

G protein-coupled receptor activity [inference]

G protein-coupled GABA receptor activity

GABA receptor activity [inference]

G protein-coupled GABA receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
G protein-coupled GABA receptor activity
gamma-aminobutyric acid signaling pathway

Displaying **all 4** entries
InterPro
GPCR family 3, C-terminal
GPCR family 3, GABA-B receptor
Periplasmic binding protein-like I
Receptor, ligand binding region

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:0080291	developmental and epileptic encephalopathy 59	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 55 in total

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Species	Gene ID	Orthologous MAtrix
Cyprinus carpio carpio	109112229	CYPCA110295
Crocodylus porosus	109313568	CROPO01786
Vulpes vulpes	112930871	VULVU26131
Pseudonaja textilis	113436559	PSETE07681
Athene cunicularia	113476310	ATHCN00082
Bos indicus x Bos taurus	113897236	BOBOX32209
Bos indicus x Bos taurus	113897237	BOBOX32209
Echeneis naucrates	115051311	ECHNA20139
Salmo trutta	115174040	SALTR106396
Salmo trutta	115175547	SALTR04976

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements