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MIRAGE

ectonucleoside triphosphate diphosphohydrolase 3

Summary

Gene Symbol

ENTPD3

Aliases

HB6
NTPDase-3

Organism

Homo sapiens (human)

External Links

NCBI Gene

956

HGNC

3365

PubChem

956

Alliance of Genome Resources

HGNC:3365

Annotation

Keyword

ATP-binding
Alternative splicing
Calcium
Cell membrane
Disulfide bond
Glycoprotein
Hydrolase
Magnesium
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O75355	CD39 antigen-like 3 Ecto-ATP diphosphohydrolase 3 Ecto-apyrase 3 HB6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleoside diphosphate catabolic process	IBA
nucleoside triphosphate catabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

organic substance metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying entries **6 - 8** of 8 in total

« First

‹ Prev

1

2
GO Term	Evidence Code	PMID
ribonucleoside triphosphate phosphatase activity	IDA	10231536 11300774
ribonucleoside triphosphate phosphatase activity	IBA
UDP phosphatase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

apyrase activity

nucleoside diphosphate phosphatase activity

ribonucleoside triphosphate phosphatase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ectonucleoside triphosphate diphosphohydrolase

Functional Category

F: Nucleotide transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
hydrolase activity
nucleotide binding

Displaying 1 entry
InterPro
Nucleoside phosphatase GDA1/CD39

Rhea

H₂O + a 2'-deoxyribonucleoside 5'-triphosphate

H⁺ + phosphate + a 2'-deoxyribonucleoside 5'-phosphate

Enzyme

3.6.1.5

PMID

15576788

H₂O + a ribonucleoside 5'-triphosphate

H⁺ + phosphate + a ribonucleoside 5'-phosphate

Enzyme

3.6.1.5

PMID

Ortholog

Displaying entries **1 - 10** of 77 in total

1

2

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5

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Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	956	Xenbase:XB-GENE-1012972
Mus musculus	215446	Xenbase:XB-GENE-1012972	MOUSE64080
Rattus norvegicus	316077		RATNO42052
Pan troglodytes	460286		PANTR30839
Canis lupus familiaris	485604		CANLF08978
Bos taurus	506087		BOVIN17301
Macaca mulatta	718311		MACMU29355
Danio rerio	100005551		DANRE10653
Monodelphis domestica	100025436		MONDO32842
Ornithorhynchus anatinus	100078824		ORNAN25679

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Last updated: August 4, 2025