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Repository for lectin-assisted multimodality data
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MIRAGE
Amyloid-beta precursor protein
Summary
- UniProt ID
- P05067
- Gene Symbol
-
- A4
- AD1
- APP
- Gene ID
- 351
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011374
- GlyConnect
- GlyGen
- P05067
- PubChem
- P05067
- The Human Metabolome Database
- HMDBP01991
- The O-GlcNAc Database
- P05067
- RaftProt
- P05067
- O-GlcNAcAtlas
- P05067
- Re-Glyco
- P05067
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Alzheimer disease
- Amyloid
- Amyloidosis
- Apoptosis
- Cell adhesion
- Cell membrane
- Cell projection
- Coated pit
- Copper
- Cytoplasm
- Cytoplasmic vesicle
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Endocytosis
- Endoplasmic reticulum
- Endosome
- Golgi apparatus
- Heparin-binding
- Iron
- Isopeptide bond
- Metal-binding
- Neurodegeneration
- Notch signaling pathway
- Nucleus
- Oxidation
- Phosphoprotein
- Proteoglycan
- Reference proteome
- Secreted
- Serine protease inhibitor
- Signal
- Sulfation
- Transmembrane helix
- Ubl conjugation
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| receptor complex |
| synapse |
| endosome |
| early endosome |
| endoplasmic reticulum |
| endoplasmic reticulum lumen |
| extracellular region |
| extracellular space |
| cytoplasm |
| mitochondrial inner membrane |
| GO Term |
|---|
| identical protein binding |
| transition metal ion binding |
Sequence
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 586 |
|
|||
| 600 |
|
|||
| 633 | O-linked (GalNAc...) threonine; partial | |||
| 649 |
|
|||
| 651 | O-linked (GalNAc...) threonine; partial | |||
| 652 | O-linked (GalNAc...) threonine; partial | |||
| 656 | O-linked (Xyl...) (chondroitin sulfate) serine; in L-APP isoforms | |||
| 659 | O-linked (HexNAc...) threonine; partial | |||
| 663 | O-linked (GalNAc...) threonine; partial | |||
| 667 | O-linked (GalNAc...) serine; partial |
G57321FI
G29068FM
G49108TO
G43417UB
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Advanced glycosylation endproduct receptor signaling | Homo sapiens |
| Amyloid fiber formation | Homo sapiens |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | Homo sapiens |
| Formyl peptide receptors bind formyl peptides and many other ligands | Homo sapiens |
| G alpha (i) signalling events | Homo sapiens |
| G alpha (q) signalling events | Homo sapiens |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | Homo sapiens |
| Lysosome Vesicle Biogenesis | Homo sapiens |
| Platelet degranulation | Homo sapiens |
| Post-translational protein phosphorylation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0070028 | APP-related cerebral amyloid angiopathy | |
| DOID:0080348 | Alzheimer's disease 1 | |
| DOID:0081292 | traumatic brain injury | |
| DOID:10652 | Alzheimer's disease | |
| DOID:1561 | cognitive disorder |
