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Dual oxidase 2

Summary

UniProt ID

Q9NRD8

Gene Symbol

DUOX2
LNOX2
THOX2

Gene ID

50506

Organism

Homo sapiens (human)

External Links

GlyGen: Q9NRD8
PubChem: Q9NRD8
The Human Metabolome Database: HMDBP03091
The O-GlcNAc Database: Q9NRD8
O-GlcNAcAtlas: Q9NRD8
Re-Glyco: Q9NRD8

Annotation

Keyword

Calcium
Cell junction
Cell membrane
Congenital hypothyroidism
Disease variant
Disulfide bond
FAD
Glycoprotein
Hydrogen peroxide
Metal-binding
NADP
Reference proteome
Repeat
Signal
Thyroid hormones biosynthesis
Transmembrane helix

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
plasma membrane
anchoring junction
endoplasmic reticulum
cytosol
cell surface
apical plasma membrane
apical part of cell
cell leading edge
NADPH oxidase complex
extracellular exosome

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 13 in total

1

2

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GO Term
response to oxidative stress
superoxide anion generation
hydrogen peroxide catabolic process
response to cAMP
cuticle development
hydrogen peroxide biosynthetic process
thyroid hormone generation
defense response
response to virus
cytokine-mediated signaling pathway

Displaying **all 7** entries
GO Term
NADH oxidase H202-forming activity
NADPH oxidase H202-forming activity
peroxidase activity
heme binding
NAD(P)H oxidase H2O2-forming activity
superoxide-generating NAD(P)H oxidase activity
calcium ion binding

Annotation information from UniProt.

Sequence

MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	GlyTouCan ID	Source
100	N-linked (GlcNAc...) asparagine		UniProt GlyGen
348	N-linked (GlcNAc...) asparagine		UniProt GlyGen
382	N-linked (GlcNAc...) asparagine		UniProt GlyGen
455	N-linked (GlcNAc...) asparagine		UniProt GlyGen
537	N-linked (GlcNAc...) asparagine		UniProt GlyGen
1007			GlyGen
1299		G49108TO	GlyGen The O-GlcNAc Database