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chloride voltage-gated channel 3

Summary

Gene Symbol

CLCN3

Organism

Oryctolagus cuniculus (rabbit)

External Links

NCBI Gene: 100008673
PubChem: 100008673

Annotation

Keyword

ATP-binding
Antiport
CBS domain
Cell membrane
Chloride
Endosome
Glycoprotein
Ion transport
Lysosome
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A5F9CZQ8
A0A5F9C5P2
O18894	Chloride channel protein 3 Chloride transporter ClC-3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
chloride transport	IEA	22301074
transmembrane transport	IEA	22301074

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport

inorganic anion transport [inference]

chloride transport

transmembrane transport

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
lysosomal membrane
early endosome	IEA	30032202
late endosome
Golgi apparatus	IEA	30032202
plasma membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
voltage-gated chloride channel activity	IEA	22301074 30032202
ATP binding
antiporter activity
PDZ domain binding

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

monoatomic anion channel activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

monoatomic anion channel activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity [inference]

voltage-gated chloride channel activity

binding [inference]

protein binding [inference]

protein domain specific binding [inference]

PDZ domain binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Chloride Channel

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
chloride transmembrane transport
chloride transport
monoatomic ion transport
voltage-gated chloride channel activity

Displaying **all 4** entries
InterPro
CBS domain superfamily
CBS domain
Chloride channel, core
Chloride channel, voltage gated

Ortholog

Displaying entries **101 - 102** of **102** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Panthera leo	122217714		PANLE26559
Ursus americanus	123793162		URSAM12036

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

GlyCosmos Portal v4.3.0

Last updated: August 4, 2025

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