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Guidelines

MIRAGE

proprotein convertase subtilisin/kexin type 9

Summary

Gene Symbol

Pcsk9

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

100102

KEGG Gene ID

PubChem

100102

Alliance of Genome Resources

MGI:2140260

Annotation

Keyword

Apoptosis
Autocatalytic cleavage
Calcium
Cholesterol metabolism
Cytoplasm
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Lysosome
Phosphoprotein
Reference proteome
Secreted
Serine protease
Signal
Sulfation
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q80W65	Neural apoptosis-regulated convertase 1 Proprotein convertase 9 Subtilisin/kexin-like protease PC9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 54 in total

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GO Term	Evidence Code	PMID
kidney development	IEP
kidney development	IEA
liver development	IEP
liver development	IEA
negative regulation of receptor recycling	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

protein metabolic process [inference]

protein processing

protein autoprocessing

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

lipoprotein metabolic process

protein maturation [inference]

protein processing

protein autoprocessing

receptor metabolic process [inference]

low-density lipoprotein receptor particle metabolic process

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

protein metabolic process [inference]

protein processing

protein autoprocessing

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

lipoprotein metabolic process

protein maturation [inference]

protein processing

protein autoprocessing

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular developmental process [inference]

cell differentiation [inference]

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

kidney development

gland development [inference]

liver development

cellular developmental process [inference]

cell differentiation [inference]

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to chemical [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to nitrogen compound [inference]

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of receptor recycling [inference]

negative regulation of receptor recycling

negative regulation of signaling [inference]

negative regulation of receptor recycling

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of cholesterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular transport [inference]

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of transmembrane transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion import across plasma membrane [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport [inference]

negative regulation of sodium ion transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion import across plasma membrane [inference]

negative regulation of sodium ion import across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion import across plasma membrane [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of monoatomic ion transport [inference]

negative regulation of sodium ion transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of monoatomic ion transport [inference]

negative regulation of sodium ion transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of cholesterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of receptor recycling

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of monoatomic ion transport [inference]

negative regulation of sodium ion transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling [inference]

negative regulation of receptor recycling

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

regulation of transmembrane transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

regulation of sodium ion import across plasma membrane [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

regulation of neuron apoptotic process

positive regulation of neuron apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of receptor catabolic process [inference]

positive regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of sodium ion transmembrane transport [inference]

negative regulation of sodium ion import across plasma membrane

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular lipid transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular sterol transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of intracellular cholesterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

negative regulation of intracellular transport [inference]

negative regulation of intracellular lipid transport [inference]

negative regulation of intracellular sterol transport [inference]

negative regulation of intracellular cholesterol transport [inference]

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

regulation of low-density lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

Displaying entries **1 - 5** of 41 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular region	IDA
extracellular region	IBA
extracellular region	IEA
extracellular region	HDA

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	ISO
endopeptidase activity	IEA
serine-type endopeptidase activity	ISS
serine-type endopeptidase activity	ISO
serine-type endopeptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

apolipoprotein receptor binding

lipoprotein particle receptor binding [inference]

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor inhibitor activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity

transporter inhibitor activity

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

sodium channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

sodium channel inhibitor activity

ion channel regulator activity [inference]

ion channel inhibitor activity [inference]

sodium channel inhibitor activity

sodium channel regulator activity [inference]

sodium channel inhibitor activity

transporter inhibitor activity

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

sodium channel inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proprotein convertase subtilisin/kexin type 9

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
hydrolase activity
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 5** entries
InterPro
Peptidase S8 propeptide/proteinase inhibitor I9 superfamily
Peptidase S8, subtilisin-related
Peptidase S8/S53 domain superfamily
Peptidase S8/S53 domain
Proteinase K-like catalytic domain

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	298296	RGD:728909
Homo sapiens	255738	HGNC:20001
Saccharomyces cerevisiae S288C	850412	SGD:S000000641
Saccharomyces cerevisiae S288C	856649	SGD:S000000786

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: April 6, 2026