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phosphatase and tensin homolog

Summary

Gene Symbol

PTEN

Organism

Pongo abelii (Sumatran orangutan)

External Links

NCBI Gene: 100171828
KEGG Gene ID: ["pon:100171828"]
PubChem: 100171828

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein dephosphorylation	IEA
negative regulation of cell population proliferation	IEA
phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
phosphatidylinositol dephosphorylation	IEA
cell motility	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

primary metabolic process [inference]

lipid metabolic process [inference]

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cell motility

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus	IEA
cytosol	IEA
plasma membrane	IEA
cell projection	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

plasma membrane

cell projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein tyrosine phosphatase activity	IEA
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IEA
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	IEA
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

inositol phosphate phosphatase activity [inference]

inositol tetrakisphosphate phosphatase activity [inference]

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

phosphatidylinositol phosphate phosphatase activity [inference]

phosphatidylinositol bisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4-bisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

phosphatidylinositol trisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phosphatase

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
cell motility
dephosphorylation
lipid metabolic process
negative regulation of cell population proliferation
phosphatidylinositol phosphate phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
protein tyrosine phosphatase activity
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Displaying **all 8** entries
InterPro
C2 domain superfamily
PTEN, phosphatase domain
Protein-tyrosine phosphatase, active site
Protein-tyrosine phosphatase, catalytic
Protein-tyrosine phosphatase-like
Tensin phosphatase, C2 domain
Tensin-type phosphatase domain
Tyrosine-specific protein phosphatases domain