GlyCosmos Portal

Annotation

Keyword

3D-structure
ATP-binding
Allosteric enzyme
Alternative splicing
Cytoplasm
Disease variant
Hydrolase
Kinase
Metal-binding
Multifunctional enzyme
Phosphoprotein
Reference proteome
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y223	UDP-GlcNAc-2-epimerase/ManAc kinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
N-acetylglucosamine biosynthetic process	IEA
UDP-N-acetylglucosamine metabolic process	IEA
CMP-N-acetylneuraminate biosynthetic process	IMP	31121216
N-acetylneuraminate biosynthetic process	IMP	14707127 31121216
carbohydrate phosphorylation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

amide metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

organonitrogen compound biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amino sugar biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

glucosamine-containing compound biosynthetic process [inference]

N-acetylglucosamine biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organonitrogen compound biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

phosphorus metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate phosphorylation

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate phosphorylation

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

amino sugar biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

glucosamine-containing compound biosynthetic process [inference]

N-acetylglucosamine biosynthetic process

glucosamine-containing compound metabolic process [inference]

N-acetylglucosamine metabolic process [inference]

N-acetylglucosamine biosynthetic process

glucosamine-containing compound biosynthetic process [inference]

N-acetylglucosamine biosynthetic process

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amino sugar biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

glucosamine-containing compound biosynthetic process [inference]

N-acetylglucosamine biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

organonitrogen compound biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amino sugar biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

glucosamine-containing compound biosynthetic process [inference]

N-acetylglucosamine biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organonitrogen compound biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate biosynthetic process

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

phosphorus metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amide biosynthetic process [inference]

N-acetylneuraminate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	ISS
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
protein binding	IPI	18560563 25416956 31515488 32296183 32814053
ATP binding	IEA
UDP-N-acetylglucosamine 2-epimerase activity	TAS
UDP-N-acetylglucosamine 2-epimerase activity	IDA	26980148 2808337

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

carbohydrate kinase activity [inference]

N-acylmannosamine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

N-acylmannosamine kinase activity

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

isomerase activity [inference]

racemase and epimerase activity [inference]

racemase and epimerase activity, acting on carbohydrates and derivatives [inference]

UDP-N-acetylglucosamine 2-epimerase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
N-acylmannosamine kinase activity
UDP-N-acetylglucosamine 2-epimerase activity
UDP-N-acetylglucosamine metabolic process
hexokinase activity
kinase activity
phosphorylation

Displaying **all 4** entries
InterPro
ATPase, nucleotide binding domain
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
ROK family
UDP-N-acetylglucosamine 2-epimerase domain

Human Protein Atlas

ENSG00000159921

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K12409

Name

bifunctional UDP-N-acetylglucosamine 2-epimerase / N-acetylmannosamine kinase [EC:3.2.1.183 2.7.1.60]

References

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080718	GNE myopathy	Glyco-Disease Genes Database Glyco-Disease Genes Database Alliance of Genome Resources
DOID:1588	thrombocytopenia	Alliance of Genome Resources
DOID:3659	sialuria	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 89 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000023	Inguinal hernia
HP:0000158	Macroglossia
HP:0000218	High palate
HP:0000219	Thin upper lip vermilion
HP:0000256	Macrocephaly
HP:0000280	Coarse facial features
HP:0000286	Epicanthus
HP:0000316	Hypertelorism

Displaying **all 4** entries
Disease ID	Disease Name
ORPHA:3166	sialuria
ORPHA:602	GNE myopathy
OMIM:605820	GNE myopathy
OMIM:269921	sialuria

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10020	Xenbase:XB-GENE-1003644
Mus musculus	50798	Xenbase:XB-GENE-1003644	MOUSE42917
Rattus norvegicus	114711	Xenbase:XB-GENE-1003644	RATNO33942
Pan troglodytes	465094		PANTR43969
Canis lupus familiaris	481607		CANLF02316
Sus scrofa	641344		PIGXX15731
Macaca mulatta	693525		MACMU12845
Takifugu rubripes	778010		TAKRU16951
Bos taurus	782201		BOVIN34583
Monodelphis domestica	100017383		MONDO30669

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements