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phospholipase C zeta 1

Summary

Gene Symbol

PLCZ1

Organism

Nomascus leucogenys (northern white-cheeked gibbon)

External Links

NCBI Gene: 100580724
KEGG Gene ID: ["nle:100580724"]
PubChem: 100580724

Annotation

Keyword

Calcium
Cytoplasm
Developmental protein
Fertilization
Hydrolase
Lipid degradation
Nucleus
Reference proteome
Transducer

Proteins

Displaying **all 2** entries
UniProt	Protein Name
G1QWP9
A0A2I3FSY6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
lipid metabolic process	IEA
calcium ion transport
lipid catabolic process	IEA
intracellular signal transduction	IEA
positive regulation of cytosolic calcium ion concentration involved in egg activation	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction

metabolic process [inference]

catabolic process [inference]

lipid catabolic process

primary metabolic process [inference]

lipid metabolic process

lipid catabolic process

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration [inference]

positive regulation of cytosolic calcium ion concentration involved in egg activation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
nucleoplasm	IEA
nucleolus	IEA
pronucleus	IEA
perinuclear region of cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

pronucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

pronucleus

intracellular membraneless organelle [inference]

nucleolus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IEA
calcium ion binding	IEA
phosphatidylinositol-4,5-bisphosphate binding	IEA
phosphatidylinositol-5-phosphate binding	IEA
phosphatidylinositol-3-phosphate binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

glycerophospholipase activity [inference]

C-type glycerophospholipase activity [inference]

phosphatidylinositol-4,5-bisphosphate phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

C-type glycerophospholipase activity [inference]

phosphatidylinositol-4,5-bisphosphate phospholipase C activity

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol phosphate binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium ion binding
hydrolase activity
lipid metabolic process
metal ion binding
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol

Displaying **all 8** entries
InterPro
C2 domain superfamily
C2 domain
EF-hand domain pair
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
Phosphoinositide-specific phospholipase C, EF-hand-like domain
Phospholipase C, phosphatidylinositol-specific, Y domain