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7-dehydrocholesterol reductase

Summary

Gene Symbol

DHCR7

Organism

Nomascus leucogenys (northern white-cheeked gibbon)

External Links

NCBI Gene: 100580795
KEGG Gene ID: nle:100580795
PubChem: 100580795

Annotation

Keyword

Cholesterol biosynthesis
Endoplasmic reticulum
NADP
Oxidoreductase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2I3G7U1	Sterol Delta(7)-reductase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cholesterol biosynthetic process	IEA	30032202
brassinosteroid biosynthetic process	IEA	30032202 http://purl.obolibrary.org/obo/go/references/0000118
cholesterol biosynthetic process via lathosterol
positive regulation of ferroptosis	IEA	http://purl.obolibrary.org/obo/go/references/0000107

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via lathosterol

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via lathosterol

hormone metabolic process [inference]

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via lathosterol

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via lathosterol

sterol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via lathosterol

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via lathosterol

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via lathosterol

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via lathosterol

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via lathosterol

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via lathosterol

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of ferroptosis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

positive regulation of programmed cell death [inference]

positive regulation of ferroptosis

regulation of ferroptosis [inference]

positive regulation of ferroptosis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of ferroptosis

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nuclear outer membrane	IEA	http://purl.obolibrary.org/obo/go/references/0000107
endoplasmic reticulum membrane	IEA	30032202 http://purl.obolibrary.org/obo/go/references/0000044 http://purl.obolibrary.org/obo/go/references/0000104 http://purl.obolibrary.org/obo/go/references/0000118

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane

nuclear membrane [inference]

nuclear outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

nuclear outer membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cholesterol-5,6-oxide hydrolase activity	IEA	http://purl.obolibrary.org/obo/go/references/0000003 http://purl.obolibrary.org/obo/go/references/0000107
7-dehydrocholesterol reductase activity	IEA	30032202 http://purl.obolibrary.org/obo/go/references/0000003 http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000117 http://purl.obolibrary.org/obo/go/references/0000118

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [inference]

7-dehydrocholesterol reductase activity

hydrolase activity [inference]

hydrolase activity, acting on ether bonds [inference]

ether hydrolase activity [inference]

cholesterol-5,6-oxide hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

reductase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
lipid metabolic process
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
oxidoreductase activity
steroid biosynthetic process
steroid metabolic process
sterol biosynthetic process