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MIRAGE

dihydrolipoamide S-succinyltransferase

Summary

Gene Symbol

DLST

Organism

Nomascus leucogenys (northern white-cheeked gibbon)

External Links

NCBI Gene: 100582804
KEGG Gene ID: nle:100582804
PubChem: 100582804

Annotation

Keyword

Acyltransferase
Lipoyl
Mitochondrion
Nucleus
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying 1 entry
UniProt	Protein Name
G1S2U6	2-oxoglutarate dehydrogenase complex component E2 Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex E2K

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
tricarboxylic acid cycle	IEA
obsolete L-lysine catabolic process to acetyl-CoA via L-saccharopine
2-oxoglutarate decarboxylation to succinyl-CoA	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

sulfur compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

sulfur compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

purine-containing compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

primary metabolic process [inference]

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

2-oxoglutarate metabolic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

purine-containing compound metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

purine-containing compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleoplasm	IEA
mitochondrial matrix	IEA
cytosol
oxoglutarate dehydrogenase complex	IEA
oxoadipate dehydrogenase complex	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

tricarboxylic acid cycle heteromeric enzyme complex [inference]

oxoglutarate dehydrogenase complex

oxidoreductase complex [inference]

alpha-ketoacid dehydrogenase complex [inference]

transferase complex [inference]

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

Displaying 1 entry
GO Term	Evidence Code	PMID
dihydrolipoyllysine-residue succinyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

S-acyltransferase activity [inference]

S-succinyltransferase activity [inference]

dihydrolipoyllysine-residue succinyltransferase activity

succinyltransferase activity [inference]

S-succinyltransferase activity [inference]

dihydrolipoyllysine-residue succinyltransferase activity

catalytic activity, acting on a protein [inference]

dihydrolipoyllysine-residue succinyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
L-lysine catabolic process to acetyl-CoA via saccharopine
dihydrolipoyllysine-residue succinyltransferase activity
tricarboxylic acid cycle

Displaying **all 6** entries
InterPro
2-oxo acid dehydrogenase, lipoyl-binding site
2-oxoacid dehydrogenase acyltransferase, catalytic domain
Biotin/lipoyl attachment
Chloramphenicol acetyltransferase-like domain superfamily
Dihydrolipoamide succinyltransferase
Single hybrid motif

KEGG BRITE Database

Orthology

K00658

Name

2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]

References

Rhea

succinyl-CoA

CoA

Enzyme

2.3.1.61

PMID

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026