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dynamin 1 like

Summary

Gene Symbol

DNM1L

Aliases

DRP1
DVLP
DYMPLE
HDYNIV
VPS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

10059

HGNC

2973

PubChem

10059

Alliance of Genome Resources

HGNC:2973

JoGo

DNM1L

TogoVar

DNM1L

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Biological rhythms
Coated pit
Cytoplasm
Cytoplasmic vesicle
Disease variant
Endocytosis
GTP-binding
Glycoprotein
Golgi apparatus
Hydrolase
Isopeptide bond
Lipid-binding
Mitochondrion outer membrane
Necrosis
Peroxisome
Phosphoprotein
Proteomics identification
Reference proteome
S-nitrosylation
Synapse
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O00429	Dnm1p/Vps1p-like protein Dynamin family member proline-rich carboxyl-terminal domain less Dynamin-like protein Dynamin-like protein 4 Dynamin-like protein IV Dynamin-related protein 1
B4DYR6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 39 in total

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GO Term	Evidence Code	PMID
mitochondrial fission	IDA
mitochondrial fission	IMP
mitochondrial fission	IBA
mitochondrial fission	IEA
calcium ion transport

GO Hierarchy

biological process

cellular process [inference]

cell death [inference]

programmed cell death

vesicle-mediated transport [inference]

endocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

mitochondrial fission

apoptotic mitochondrial changes [inference]

mitochondrial fragmentation involved in apoptotic process

endoplasmic reticulum organization

organelle fission [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization

membrane organization [inference]

membrane fission [inference]

mitochondrial membrane fission

export from cell [inference]

migracytosis [inference]

mitocytosis

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

heart process [inference]

heart contraction

rhythmic process

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport

calcium ion transport

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

export from cell [inference]

migracytosis [inference]

mitocytosis

establishment of organelle localization [inference]

establishment of mitochondrion localization [inference]

mitocytosis

organelle localization [inference]

mitochondrion localization [inference]

mitochondrion distribution

establishment of mitochondrion localization [inference]

mitocytosis

establishment of organelle localization [inference]

establishment of mitochondrion localization [inference]

mitocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrial fission

positive regulation of secretion by cell

positive regulation of protein secretion

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of developmental process [inference]

positive regulation of mitochondrial fission

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of mitochondrial fission [inference]

positive regulation of mitochondrial fission

positive regulation of developmental process [inference]

positive regulation of mitochondrial fission

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy [inference]

regulation of mitophagy

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy

regulation of phosphorus metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of ATP metabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of ATP metabolic process

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of ATP metabolic process

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrial fission

positive regulation of secretion by cell

positive regulation of protein secretion

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrial fission

regulation of mitochondrion organization

regulation of mitochondrial fission [inference]

positive regulation of mitochondrial fission

regulation of peroxisome organization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrial fission

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell

positive regulation of protein secretion

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of granulocyte chemotaxis [inference]

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil chemotaxis

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GO Term	Evidence Code	PMID
cytoplasm	IDA
cytoplasm	IMP
cytoplasm	IBA
mitochondrion	IDA
mitochondrion	IMP

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

membrane

clathrin-coated pit

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

mitochondrion-derived vesicle

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

mitochondrion-derived vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

mitochondrion-derived vesicle

perinuclear region of cytoplasm

cluster of actin-based cell projections [inference]

brush border

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

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GO Term	Evidence Code	PMID
GTPase activity	EXP
GTPase activity	IDA
GTPase activity	IBA
GTPase activity	IEA
GTPase activator activity	IC

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

GTPase binding [inference]

small GTPase binding

GTP-dependent protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dynamin

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis

Displaying **all 3** entries
Gene Ontology
GTP binding
microtubule binding
nucleotide binding

Displaying **all 9** entries
InterPro
Dynamin GTPase effector
Dynamin stalk domain
Dynamin, GTPase domain
Dynamin, GTPase region, conserved site
Dynamin, N-terminal
Dynamin-type guanine nucleotide-binding (G) domain
Dynamin
GTPase effector domain
P-loop containing nucleoside triphosphate hydrolase

Human Protein Atlas

ENSG00000087470

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:19669

H₂O + GTP

H⁺ + phosphate + GDP

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070347	encephalopathy due to defective mitochondrial and peroxisomal fission 1	Alliance of Genome Resources
DOID:0111438	optic atrophy 5	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000135	Hypogonadism
HP:0000252	Microcephaly
HP:0000307	Pointed chin
HP:0000407	Sensorineural hearing impairment
HP:0000486	Strabismus
HP:0000490	Deeply set eye
HP:0000505	Visual impairment
HP:0000508	Ptosis

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:610708	optic atrophy 5
OMIM:614388	encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1
ORPHA:330050	encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1
ORPHA:98673	autosomal dominant optic atrophy, classic form

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements