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phosphatidylethanolamine N-methyltransferase

Summary

Gene Symbol

PEMT

Organism

Saimiri boliviensis (Bolivian squirrel monkey)

External Links

NCBI Gene: 101027664
KEGG Gene ID: sbq:101027664
PubChem: 101027664

Annotation

Keyword

Endoplasmic reticulum
Methyltransferase
Mitochondrion
Phospholipid biosynthesis
Reference proteome
S-adenosyl-L-methionine
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A2K6S041	Phospholipid methyltransferase
A0A2K6S019	Phospholipid methyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
blastocyst hatching
phosphatidylcholine biosynthetic process	IEA
sphingomyelin biosynthetic process
methylation
positive regulation of cold-induced thermogenesis	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

methylation

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

multicellular organismal process [inference]

organism emergence from protective structure [inference]

hatching [inference]

blastocyst hatching

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA
cytosol
mitochondrial membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

organelle membrane [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phosphatidyl-N-methylethanolamine N-methyltransferase activity	IEA
phosphatidylethanolamine N-methyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

N-methyltransferase activity [inference]

S-adenosylmethionine-dependent methyltransferase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:32735

S-adenosyl-L-methionine + 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine

H⁺ + S-adenosyl-L-homocysteine + 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine

Enzyme

2.1.1.71

PMID

RHEA:11164

S-adenosyl-L-methionine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine

H⁺ + S-adenosyl-L-homocysteine + 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine

Enzyme

2.1.1.17

PMID

RHEA:32739

S-adenosyl-L-methionine + 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine

H⁺ + a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine

Enzyme

2.1.1.71

PMID

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Last updated: April 6, 2026

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