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Guidelines

MIRAGE

hyaluronidase 3

Summary

Gene Symbol

HYAL3

Organism

Gorilla gorilla gorilla (western lowland gorilla)

External Links

NCBI Gene: 101152349
KEGG Gene ID: ggo:101152349
PubChem: 101152349

Annotation

Keyword

Cell membrane
Cytoplasmic vesicle
Disulfide bond
Endoplasmic reticulum
Endosome
Fertilization
Glycosidase
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
G3QVY8
A0A2I2Z1W2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
ovarian follicle atresia
carbohydrate metabolic process	IEA	22301074 30032202
inflammatory response
penetration of zona pellucida
response to virus

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

reproductive process [inference]

developmental process involved in reproduction [inference]

ovarian follicle atresia

multicellular organismal reproductive process [inference]

penetration of zona pellucida

multicellular organismal process [inference]

multi-multicellular organism process [inference]

penetration of zona pellucida

developmental process [inference]

developmental process involved in reproduction [inference]

ovarian follicle atresia

anatomical structure development [inference]

animal organ development [inference]

cartilage development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

response to UV-B [inference]

cellular response to UV-B

cellular response to UV [inference]

cellular response to UV-B

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

response to interleukin-1 [inference]

cellular response to interleukin-1

cellular response to cytokine stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

response to antibiotic

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of acrosomal vesicle exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of acrosomal vesicle exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

positive regulation of reproductive process [inference]

positive regulation of acrosomal vesicle exocytosis

negative regulation of biological process [inference]

negative regulation of developmental process [inference]

negative regulation of ovarian follicle development

negative regulation of reproductive process [inference]

negative regulation of ovarian follicle development

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of ovarian follicle development

regulation of ovarian follicle development [inference]

negative regulation of ovarian follicle development

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of acrosomal vesicle exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of regulated secretory pathway [inference]

regulation of calcium ion-dependent exocytosis [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of acrosomal vesicle exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of calcium ion-dependent exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of reproductive process [inference]

negative regulation of reproductive process [inference]

negative regulation of ovarian follicle development

positive regulation of reproductive process [inference]

positive regulation of acrosomal vesicle exocytosis

regulation of ovarian follicle development [inference]

negative regulation of ovarian follicle development

regulation of acrosomal vesicle exocytosis [inference]

positive regulation of acrosomal vesicle exocytosis

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	IEA	30032202
acrosomal membrane
extracellular region
lysosome
early endosome

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

acrosomal membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

acrosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

sperm midpiece

Displaying **all 2** entries
GO Term	Evidence Code	PMID
hyalurononglucosaminidase activity	IEA	22301074 30032202
hyaluronoglucuronidase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

hexosaminidase activity [inference]

hyalurononglucosaminidase activity

hyaluronoglucuronidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Hyaluronidase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
hyaluronan catabolic process
hyalurononglucosaminidase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity

Displaying **all 3** entries
InterPro
Aldolase-type TIM barrel
Glycoside hydrolase superfamily
Hyaluronidase

KEGG BRITE Database

Orthology

K01197

Name

hyaluronoglucosaminidase [EC:3.2.1.35]

References

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R07824	3.2.1.35	G81393WR	G92988PL
R07825	3.2.1.35	G34586BV	G92988PL
R10905	3.2.1.35	G16235VG	G16235VG G93263XO

Ortholog

Displaying entries **31 - 40** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Chinchilla lanigera	102028465		CHILA22630
Capra hircus	102172770		CAPHI14690
Myotis lucifugus	102421760		MYOLU18784
Chlorocebus sabaeus	103227669		CHLSB10379
Carlito syrichta	103255460		CARSF12171
Ursus maritimus	103674799		URSMA11926
Rhinopithecus roxellana	104667040		RHIRO13915
Pteropus vampyrus	105295149		PTEVA09221
Macaca nemestrina	105480479		MACNE07085
Mandrillus leucophaeus	105548985		MANLE24086

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Last updated: August 4, 2025