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ALG3 alpha-1,3- mannosyltransferase

Summary

Gene Symbol

ALG3

Aliases

CDGS4
D16Ertd36e
NOT56L
Not56
carbohydrate deficient glycoprotein syndrome type IV
dol-P-Man dependent alpha-1,3- mannosyltransferase
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

10195

GGDB ID

gg144

HGNC

23056

mRNA

NM_005787

map

3q27.1

Protein

NP_005778

OMIM

608750

KEGG Gene ID

["hsa:10195"]

PubChem

10195

Alliance of Genome Resources

HGNC:23056

JoGo

ALG3

TogoVar

ALG3

Annotation

Keyword

Alternative splicing
Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Glycosyltransferase
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92685	Asparagine-linked glycosylation protein 3 homolog Dol-P-Man-dependent alpha(1-3)-mannosyltransferase Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase Not56-like protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation	IDA
protein N-linked glycosylation	IEA
dolichol-linked oligosaccharide biosynthetic process	TAS
dolichol-linked oligosaccharide biosynthetic process	IDA
glycoprotein biosynthetic process	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process

protein N-linked glycosylation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process

protein N-linked glycosylation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA
endoplasmic reticulum membrane	IEA
lumenal side of endoplasmic reticulum membrane	IC

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mannosyltransferase activity	IEA
alpha-1,3-mannosyltransferase activity	TAS
protein binding	IPI
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity	IDA
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

mannosyltransferase activity

alpha-1,3-mannosyltransferase activity

dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity

GlcNAc(2)-PP-Dol mannosyltransferase activity [inference]

dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 2** entries
Gene Ontology
dol-P-Man
mannosyltransferase activity

Displaying 1 entry
InterPro
Glycosyltransferase, ALG3

Human Protein Atlas

ENSG00000214160

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg144

Gene Symbol

ALG3

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
Dol-P-Man	G59406KS		G44865OQ

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
Dol-P-Man	G59406KS		G44865OQ

Orthologous Gene

Displaying **all 6** entries
Species	Protein	mRNA
Caenorhabditis elegans	NP_496950	NM_064549
Mus musculus	NP_666051	NM_145939
Saccharomyces cerevisiae	CAA84904	Z35844
Drosophila melanogaster	NP_523829	NM_079105
Rattus norvegicus	XP_237830	XM_237830
Arabidopsis thaliana	NP_182297	NM_130343

KEGG BRITE Database

Orthology

K03845

Name

alpha-1,3-mannosyltransferase [EC:2.4.1.258]

References

18567790

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R06258	2.4.1.258	G59406KS G74840NI	G44865OQ

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080556	congenital disorder of glycosylation Id	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 75 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000119	Abnormality of the genitourinary system
HP:0000158	Macroglossia
HP:0000172	Abnormal uvula morphology
HP:0000193	Bifid uvula
HP:0000218	High palate
HP:0000252	Microcephaly
HP:0000286	Epicanthus
HP:0000365	Hearing impairment
HP:0000366	Abnormality of the nose