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ATP binding cassette subfamily C member 4 (PEL blood group)

Summary

Gene Symbol

ABCC4

Organism

Homo sapiens (human)

External Links

NCBI Gene

10257

PubChem

10257

Alliance of Genome Resources

HGNC:55

JoGo

ABCC4

TogoVar

ABCC4

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Disease variant
Glycoprotein
Lipid transport
Magnesium
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Translocase
Transmembrane helix
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8K2Q2
O15439	MRP/cMOAT-related ABC transporter Multi-specific organic anion transporter B Multidrug resistance-associated protein 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
platelet degranulation	TAS	https://reactome.org/content/detail/R-HSA-114608
L-tryptophan metabolic process
xenobiotic metabolic process	TAS	https://reactome.org/content/detail/R-HSA-9753281
xenobiotic transmembrane transport	TAS	https://reactome.org/content/detail/R-HSA-9750546
bile acid and bile salt transport	IMP	16282361

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

xenobiotic metabolic process

indole-containing compound metabolic process [inference]

L-tryptophan metabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

L-tryptophan metabolic process

proteinogenic amino acid metabolic process [inference]

L-tryptophan metabolic process

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

L-tryptophan metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

L-tryptophan metabolic process

monocarboxylic acid metabolic process [inference]

kynurenic acid metabolic process

proteinogenic amino acid metabolic process [inference]

L-tryptophan metabolic process

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

L-tryptophan metabolic process

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

transmembrane transport

xenobiotic transmembrane transport

oligopeptide transmembrane transport [inference]

tripeptide transmembrane transport [inference]

glutathione transmembrane transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport

export across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

signal release [inference]

prostaglandin secretion

export across plasma membrane

lipid export from cell [inference]

prostaglandin secretion

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

bile acid and bile salt transport

fatty acid transport [inference]

prostaglandin transport

prostaglandin secretion

lipid export from cell [inference]

prostaglandin secretion

vascular transport [inference]

transport across blood-brain barrier

organic anion transport [inference]

urate transport

glutathione transport [inference]

glutathione transmembrane transport

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

fatty acid transport [inference]

prostaglandin transport

prostaglandin secretion

icosanoid transport [inference]

prostaglandin transport

prostaglandin secretion

icosanoid secretion [inference]

prostaglandin secretion

leukotriene transport

cAMP transport

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport

purine ribonucleotide transport [inference]

cAMP transport

adenine nucleotide transport [inference]

cAMP transport

cyclic nucleotide transport [inference]

cAMP transport

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport

peptide transport [inference]

oligopeptide transport [inference]

oligopeptide transmembrane transport [inference]

tripeptide transmembrane transport [inference]

glutathione transmembrane transport

tripeptide transport [inference]

glutathione transport [inference]

glutathione transmembrane transport

tripeptide transmembrane transport [inference]

glutathione transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

fatty acid transport [inference]

prostaglandin transport

prostaglandin secretion

icosanoid transport [inference]

prostaglandin transport

prostaglandin secretion

icosanoid secretion [inference]

prostaglandin secretion

leukotriene transport

organic hydroxy compound transport [inference]

bile acid and bile salt transport

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

xenobiotic transport [inference]

xenobiotic transmembrane transport

secretion [inference]

icosanoid secretion [inference]

prostaglandin secretion

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

signal release [inference]

prostaglandin secretion

transmembrane transport

xenobiotic transmembrane transport

oligopeptide transmembrane transport [inference]

tripeptide transmembrane transport [inference]

glutathione transmembrane transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport

export across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport

nitrogen compound transport [inference]

oligopeptide transport [inference]

oligopeptide transmembrane transport [inference]

tripeptide transmembrane transport [inference]

glutathione transmembrane transport

tripeptide transport [inference]

glutathione transport [inference]

glutathione transmembrane transport

tripeptide transmembrane transport [inference]

glutathione transmembrane transport

urate transport

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport

purine ribonucleotide transport [inference]

cAMP transport

adenine nucleotide transport [inference]

cAMP transport

cyclic nucleotide transport [inference]

cAMP transport

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport

modified amino acid transport [inference]

glutathione transport [inference]

glutathione transmembrane transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport

sulfur compound transport [inference]

glutathione transport [inference]

glutathione transmembrane transport

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

signal release [inference]

prostaglandin secretion

export across plasma membrane

lipid export from cell [inference]

prostaglandin secretion

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

cAMP transport

establishment of localization in cell [inference]

platelet degranulation

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
nucleolus
Golgi apparatus
plasma membrane	TAS	https://reactome.org/content/detail/R-HSA-1454916 https://reactome.org/content/detail/R-HSA-9750546 https://reactome.org/content/detail/R-HSA-9753283 https://reactome.org/content/detail/R-HSA-9753284
plasma membrane	IDA	15297306 18619525 23137377 25173977 28112518 http://purl.obolibrary.org/obo/go/references/0000052
plasma membrane	IBA	http://purl.obolibrary.org/obo/go/references/0000033

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

platelet dense granule membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

platelet dense granule membrane

plasma membrane region [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular membraneless organelle [inference]

nucleolus

side of membrane [inference]

external side of plasma membrane [inference]

external side of apical plasma membrane

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
guanine nucleotide transmembrane transporter activity	IDA	15454390
protein binding	IPI	22411990 24550280 29146910 33961781 36115835
ATP binding	IEA	http://purl.obolibrary.org/obo/go/references/0000002 http://purl.obolibrary.org/obo/go/references/0000104
ABC-type xenobiotic transporter activity	EXP	11856762 12105214 15454390 17344354 18300232
ABC-type xenobiotic transporter activity	IEA	http://purl.obolibrary.org/obo/go/references/0000003

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity

efflux transmembrane transporter activity

organophosphate ester transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity

guanine nucleotide transmembrane transporter activity

nucleobase-containing compound transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity

guanine nucleotide transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled lipid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ABC-type transporter activity

oligopeptide transmembrane transporter activity [inference]

tripeptide transmembrane transporter activity [inference]

glutathione transmembrane transporter activity

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

bile acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

modified amino acid transmembrane transporter activity [inference]

glutathione transmembrane transporter activity

lipid transmembrane transporter activity [inference]

bile acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled lipid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

icosanoid transmembrane transporter activity [inference]

prostaglandin transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

salt transmembrane transporter activity [inference]

urate transmembrane transporter activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled lipid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ABC-type transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

multidrug resistance-associated

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements