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serine palmitoyltransferase long chain base subunit 2

Summary

Gene Symbol

SPTLC2

Organism

Physeter macrocephalus (sperm whale)

External Links

NCBI Gene: 102973502
KEGG Gene ID: pcad:102973502
PubChem: 102973502

Annotation

Keyword

Acyltransferase
Endoplasmic reticulum
Pyridoxal phosphate
Reference proteome
Sphingolipid metabolism
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A2Y9TI69
A0A9W2WZJ0
A0A2Y9TKY7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
sphingomyelin biosynthetic process	IEA	http://purl.obolibrary.org/obo/go/references/0000107
sphinganine biosynthetic process
sphingosine biosynthetic process	IEA	30032202 http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000118
ceramide biosynthetic process	IEA	30032202 http://purl.obolibrary.org/obo/go/references/0000118
adipose tissue development	IEA	http://purl.obolibrary.org/obo/go/references/0000107

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

sphingoid metabolic process [inference]

sphinganine metabolic process [inference]

sphinganine biosynthetic process

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphinganine metabolic process [inference]

sphinganine biosynthetic process

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

connective tissue development [inference]

adipose tissue development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of lipophagy

regulation of cellular process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of lipophagy

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of lipophagy

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of lipophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of lipophagy

regulation of lipophagy [inference]

positive regulation of lipophagy

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of lipophagy

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA	http://purl.obolibrary.org/obo/go/references/0000044
endoplasmic reticulum membrane	IEA	http://purl.obolibrary.org/obo/go/references/0000044
membrane	IEA	http://purl.obolibrary.org/obo/go/references/0000044
serine palmitoyltransferase complex	IEA	30032202 http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000118

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

palmitoyltransferase complex [inference]

serine palmitoyltransferase complex

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
serine C-palmitoyltransferase activity	IEA	30032202 http://purl.obolibrary.org/obo/go/references/0000003 http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000118
pyridoxal phosphate binding	IEA	22301074 http://purl.obolibrary.org/obo/go/references/0000002

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

C-acyltransferase activity [inference]

C-palmitoyltransferase activity [inference]

serine C-palmitoyltransferase activity

palmitoyltransferase activity [inference]

C-palmitoyltransferase activity [inference]

serine C-palmitoyltransferase activity

binding [inference]

small molecule binding [inference]

vitamin binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

ion binding [inference]

anion binding [inference]

pyridoxal phosphate binding

heterocyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Serine palmitoyltransferase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
catalytic activity
ceramide biosynthetic process
pyridoxal phosphate binding
serine C-palmitoyltransferase activity
sphingosine biosynthetic process
transferase activity

Displaying **all 4** entries
InterPro
Aminotransferase, class I/classII
Pyridoxal phosphate-dependent transferase, major domain
Pyridoxal phosphate-dependent transferase, small domain
Pyridoxal phosphate-dependent transferase