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Guidelines

MIRAGE

arylformamidase

Summary

Gene Symbol

AFMID

Organism

Physeter macrocephalus (sperm whale)

External Links

NCBI Gene: 102976260
KEGG Gene ID: pcad:102976260
PubChem: 102976260

Annotation

Keyword

Cytoplasm
Hydrolase
Nucleus
Reference proteome
Signal
Tryptophan catabolism

Proteins

Displaying **all 7** entries
UniProt	Protein Name
A0A9W2WJB7
A0A2Y9EDE7	Arylformamidase N-formylkynurenine formamidase
A0A2Y9EDR9	Arylformamidase N-formylkynurenine formamidase
A0A2Y9EE79	Arylformamidase N-formylkynurenine formamidase
A0A2Y9ECZ6	Arylformamidase N-formylkynurenine formamidase
A0A2Y9ECH4	Arylformamidase N-formylkynurenine formamidase
A0A2Y9EE86	Arylformamidase N-formylkynurenine formamidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
obsolete L-tryptophan catabolic process to L-kynurenine
'de novo' NAD+ biosynthetic process from L-tryptophan	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

NAD+ metabolic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nicotinamide nucleotide metabolic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

NAD+ metabolic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

NAD+ metabolic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nicotinamide nucleotide metabolic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

NAD+ metabolic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine-containing compound biosynthetic process [inference]

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

indole-containing compound metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

NAD+ metabolic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nicotinamide nucleotide metabolic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

NAD+ metabolic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

proteinogenic amino acid metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

proteinogenic amino acid metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

NAD+ metabolic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nicotinamide nucleotide metabolic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

NAD+ metabolic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

NAD+ metabolic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine-containing compound metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

NAD+ metabolic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

pyridine-containing compound biosynthetic process [inference]

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleus	IEA
cytosol	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
arylformamidase activity	IEA
lipase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

arylformamidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Kynurenine formamidase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hydrolase activity
lipase activity

Displaying 1 entry
InterPro
Alpha/Beta hydrolase fold

KEGG BRITE Database

Orthology

K01432

Name

arylformamidase [EC:3.5.1.9]

References

12007602

Rhea

H₂O + N-formyl-L-kynurenine

H⁺ + formate + L-kynurenine

Enzyme

3.5.1.9

PMID

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026