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Guidelines

MIRAGE

alcohol dehydrogenase 5 (class III), chi polypeptide

Summary

Gene Symbol

ADH5

Organism

Physeter macrocephalus (sperm whale)

External Links

NCBI Gene: 102977780
KEGG Gene ID: ["pcad:102977780"]
PubChem: 102977780

Annotation

Keyword

Acetylation
Cytoplasm
Metal-binding
NAD
Oxidoreductase
Reference proteome
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2Y9FI76

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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2

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GO Term	Evidence Code	PMID
retinoid metabolic process
respiratory system process
fatty acid omega-oxidation	IEA
response to lipopolysaccharide
positive regulation of blood pressure

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

formaldehyde metabolic process [inference]

formaldehyde catabolic process

catabolic process [inference]

small molecule catabolic process [inference]

formaldehyde catabolic process

aldehyde catabolic process [inference]

formaldehyde catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

small molecule catabolic process [inference]

formaldehyde catabolic process

formaldehyde metabolic process [inference]

formaldehyde catabolic process

cellular detoxification [inference]

cellular detoxification of aldehyde [inference]

formaldehyde catabolic process

multicellular organismal process [inference]

system process [inference]

respiratory system process

response to stimulus [inference]

response to stress [inference]

response to nitrosative stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to lipid [inference]

response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide

response to redox state

biological regulation [inference]

regulation of biological quality [inference]

regulation of blood pressure [inference]

positive regulation of blood pressure

detoxification [inference]

cellular detoxification [inference]

cellular detoxification of aldehyde [inference]

formaldehyde catabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion
cytosol	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
alcohol dehydrogenase (NAD+) activity	IEA
fatty acid binding	IEA
zinc ion binding	IEA
formaldehyde dehydrogenase (NAD+) activity	IEA
identical protein binding

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

alcohol dehydrogenase [NAD(P)+] activity [inference]

alcohol dehydrogenase (NAD+) activity

S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity

S-nitrosoglutathione reductase (NADH) activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity [inference]

formaldehyde dehydrogenase (NAD+) activity

binding [inference]

protein binding [inference]

identical protein binding

lipid binding [inference]

fatty acid binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

fatty acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

fatty acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dehydrogenase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
S-(hydroxymethyl)glutathione dehydrogenase activity
alcohol dehydrogenase activity, zinc-dependent
ethanol oxidation
formaldehyde catabolic process
metal ion binding
oxidoreductase activity
zinc ion binding

Displaying **all 6** entries
InterPro
Alcohol dehydrogenase class III
Alcohol dehydrogenase, zinc-type, conserved site
Alcohol dehydrogenase-like, C-terminal
Alcohol dehydrogenase-like, N-terminal
GroES-like superfamily
NAD(P)-binding domain superfamily

KEGG BRITE Database

Orthology

K00121

Name

S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]

References

Rhea

NADP⁺ + S-(hydroxymethyl)glutathione

H⁺ + S-formylglutathione + NADPH

Enzyme

1.1.1.284

PMID

NAD⁺ + S-(hydroxymethyl)glutathione

H⁺ + S-formylglutathione + NADH

Enzyme

1.1.1.284

PMID

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026