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hyaluronidase 2

Summary

Gene Symbol

HYAL2

Organism

Physeter catodon (sperm whale)

External Links

NCBI Gene: 102995474
KEGG Gene ID: pcad:102995474
PubChem: 102995474

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Glycosidase
Receptor
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2Y9EZP8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 27 in total

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GO Term	Evidence Code	PMID
hyaluronan catabolic process	IEA	30032202
negative regulation of cell growth
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
monocyte activation

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

monocyte activation

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

monocyte activation

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane fusion [inference]

fusion of virus membrane with host plasma membrane

viral process [inference]

membrane fusion involved in viral entry into host cell [inference]

fusion of virus membrane with host plasma membrane

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

monocyte activation

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

skeletal system morphogenesis

anatomical structure development [inference]

animal organ development [inference]

cartilage development

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

multicellular organismal-level iron ion homeostasis

inorganic ion homeostasis [inference]

multicellular organismal-level iron ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to oxidative stress [inference]

response to reactive oxygen species

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

response to UV-B [inference]

cellular response to UV-B

cellular response to UV [inference]

cellular response to UV-B

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

response to transforming growth factor beta [inference]

cellular response to transforming growth factor beta stimulus

response to fibroblast growth factor [inference]

cellular response to fibroblast growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

response to interleukin-1 [inference]

cellular response to interleukin-1

cellular response to cytokine stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

response to antibiotic

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

response to oxygen-containing compound [inference]

response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of interleukin-8 production [inference]

positive regulation of interleukin-8 production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of interleukin-8 production [inference]

positive regulation of interleukin-8 production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein tyrosine kinase activity [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein tyrosine kinase activity [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein tyrosine kinase activity [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of interleukin-8 production [inference]

positive regulation of interleukin-8 production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein tyrosine kinase activity [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein tyrosine kinase activity [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

negative regulation of fibroblast migration

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cell growth

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of interleukin-8 production [inference]

positive regulation of interleukin-8 production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein tyrosine kinase activity [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein tyrosine kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein tyrosine kinase activity [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cell growth

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of peptidyl-tyrosine phosphorylation [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

negative regulation of fibroblast migration

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of interleukin-8 production [inference]

positive regulation of interleukin-8 production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein tyrosine kinase activity [inference]

negative regulation of protein tyrosine kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein tyrosine kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
endocytic vesicle
cytoplasmic vesicle	IEA	30032202
membrane raft
perinuclear region of cytoplasm
RNA polymerase II transcription regulator complex

GO Hierarchy

cellular component

protein-containing complex [inference]

transcription regulator complex [inference]

RNA polymerase II transcription regulator complex

nuclear protein-containing complex [inference]

RNA polymerase II transcription regulator complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

membrane microdomain [inference]

membrane raft

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endocytic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle

endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle

endocytic vesicle

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
receptor tyrosine kinase binding
hyaluronoglucuronidase activity	IEA	30032202
transforming growth factor beta binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

hexosaminidase activity [inference]

hyalurononglucosaminidase activity

hyaluronoglucuronidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor tyrosine kinase binding

growth factor binding [inference]

transforming growth factor beta binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

cytokine binding [inference]

transforming growth factor beta binding

exogenous protein binding [inference]

virus receptor activity

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

hyaluronic acid binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein tyrosine kinase inhibitor activity [inference]

receptor signaling protein tyrosine kinase inhibitor activity

kinase regulator activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein tyrosine kinase inhibitor activity [inference]

receptor signaling protein tyrosine kinase inhibitor activity

protein kinase regulator activity [inference]

protein kinase inhibitor activity [inference]

protein tyrosine kinase inhibitor activity [inference]

receptor signaling protein tyrosine kinase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein tyrosine kinase inhibitor activity [inference]

receptor signaling protein tyrosine kinase inhibitor activity

transcription regulator activity [inference]

transcription coregulator activity [inference]

transcription coactivator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Hyaluronidase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
hyaluronan catabolic process
hyalurononglucosaminidase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity

Displaying **all 3** entries
InterPro
Aldolase-type TIM barrel
Glycoside hydrolase superfamily
Hyaluronidase

KEGG BRITE Database

Orthology

K01197

Name

hyaluronoglucosaminidase [EC:3.2.1.35]

References

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R07824	3.2.1.35	G81393WR	G92988PL
R10905	3.2.1.35	G16235VG	G16235VG G93263XO
R07825	3.2.1.35	G34586BV	G92988PL

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements