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adenosine deaminase RNA specific

Summary

Gene Symbol

ADAR

Aliases

ADAR1
DRADA
Double-stranded RNA-specific adenosine deaminase

Organism

Homo sapiens (human)

External Links

NCBI Gene

103

HGNC

225

PubChem

103

Alliance of Genome Resources

HGNC:225

JoGo

ADAR

TogoVar

ADAR

Annotation

Keyword

3D-structure
Aicardi-Goutieres syndrome
Alternative promoter usage
Alternative splicing
Antiviral defense
Cytoplasm
DNA-binding
Direct protein sequencing
Disease variant
Hydrolase
Innate immunity
Isopeptide bond
Metal-binding
Methylation
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
RNA-mediated gene silencing
Reference proteome
Repeat
Ubl conjugation
Zinc
mRNA processing

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P55265	136 kDa double-stranded RNA-binding protein Interferon-inducible protein 4 K88DSRBP
A0AAQ5BGH8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
osteoblast differentiation
hematopoietic progenitor cell differentiation
somatic diversification of immune receptors via somatic mutation
adenosine to inosine editing	IDA
adenosine to inosine editing	IMP

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via somatic mutation

immune response [inference]

innate immune response

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

mRNA modification

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

mRNA modification

mRNA metabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

mRNA modification

mRNA metabolic process [inference]

RNA processing

mRNA processing

regulatory ncRNA processing [inference]

miRNA processing [inference]

pre-miRNA processing

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

epithelial cell apoptotic process [inference]

hepatocyte apoptotic process

intercellular transport [inference]

nuclear export [inference]

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

hematopoietic stem cell homeostasis

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

hematopoietic stem cell homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

response to interferon-alpha

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

nuclear export [inference]

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

protein transport [inference]

intracellular protein transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of viral process [inference]

positive regulation of viral genome replication

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of hepatocyte apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral genome replication

regulation of viral life cycle [inference]

regulation of viral genome replication [inference]

positive regulation of viral genome replication

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of hepatocyte apoptotic process

regulation of epithelial cell apoptotic process [inference]

regulation of hepatocyte apoptotic process [inference]

negative regulation of hepatocyte apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of hepatocyte apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of hepatocyte apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of hepatocyte apoptotic process

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of transferase activity [inference]

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
nucleus	EXP
nucleus	TAS
nucleus	IDA
nucleus	IEA
nucleoplasm	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

spliceosomal complex [inference]

supraspliceosomal complex

ribonucleoprotein complex [inference]

spliceosomal complex [inference]

supraspliceosomal complex

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

nuclear lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
DNA binding
RNA binding	IEA
RNA binding	HDA
double-stranded RNA binding	IBA
double-stranded RNA adenosine deaminase activity	EXP

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [inference]

adenosine deaminase activity

tRNA-specific adenosine deaminase activity

deaminase activity [inference]

double-stranded RNA adenosine deaminase activity

adenosine deaminase activity

tRNA-specific adenosine deaminase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

tRNA-specific adenosine deaminase activity

binding [inference]

nucleic acid binding [inference]

DNA binding

RNA binding

double-stranded RNA binding

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Double-stranded RNA-specific adenosine deaminase

Functional Category

K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
adenosine deaminase activity
adenosine to inosine editing
double-stranded RNA binding
tRNA-specific adenosine deaminase activity

Displaying **all 7** entries
InterPro
ADAR1, first double-stranded RNA binding domain
ADAR1, third double-stranded RNA binding domain
Adenosine deaminase/editase
Double-stranded RNA-binding domain
Winged helix DNA-binding domain superfamily
Winged helix-like DNA-binding domain superfamily
Z-binding domain

Human Protein Atlas

ENSG00000160710

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:10120

H₂O + H⁺

NH₄⁺

Enzyme

3.5.4.37

PMID

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050629	Aicardi-Goutieres syndrome	Alliance of Genome Resources
DOID:0060257	dyschromatosis symmetrica hereditaria	Alliance of Genome Resources
DOID:11166	Human papillomavirus infectious disease	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of **118** in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000054	Micropenis
HP:0000252	Microcephaly
HP:0000369	Low-set ears
HP:0000444	Convex nasal ridge
HP:0000496	Abnormality of eye movement
HP:0000501	Glaucoma
HP:0000508	Ptosis
HP:0000625	Eyelid coloboma

Displaying **all 5** entries
Disease ID	Disease Name
ORPHA:41	dyschromatosis symmetrica hereditaria
ORPHA:51	Aicardi-Goutieres syndrome
OMIM:127400	dyschromatosis symmetrica hereditaria
ORPHA:225154	familial infantile bilateral striatal necrosis
OMIM:615010	Aicardi-Goutieres syndrome 6

PubChem Disease

GHR Health Conditions

Aicardi-Goutières syndrome

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements