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C-type lectin domain family 4 member M

Summary

Gene Symbol

CLEC4M

Organism

Homo sapiens (human)

External Links

NCBI Gene

10332

PubChem

10332

Alliance of Genome Resources

HGNC:13523

JoGo

CLEC4M

TogoVar

CLEC4M

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Calcium
Cell membrane
Disulfide bond
Endocytosis
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Innate immunity
Mannose-binding
Metal-binding
Proteomics identification
Receptor
Reference proteome
Repeat
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9H2X3	CD209 antigen-like protein 1 DC-SIGN-related protein Dendritic cell-specific ICAM-3-grabbing non-integrin 2 Liver/lymph node-specific ICAM-3-grabbing non-integrin
A0A7P0MMK7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
adaptive immune response	IEA
immune response	IBA
leukocyte cell-cell adhesion	NAS	11337487
cell-cell recognition	TAS	11337487
virion attachment to host cell	TAS	11337487

GO Hierarchy

biological process

immune system process [inference]

immune response

antigen processing and presentation

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

leukocyte cell-cell adhesion

signal transduction [inference]

intracellular signal transduction

cell recognition [inference]

cell-cell recognition

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

viral process [inference]

viral genome replication

transport of virus [inference]

intracellular transport of virus

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

adhesion of symbiont to host [inference]

adhesion of symbiont to host cell [inference]

virion attachment to host cell

receptor-mediated virion attachment to host cell

symbiont entry into host [inference]

symbiont entry into host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

intracellular transport of virus

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

localization [inference]

establishment of localization [inference]

transport [inference]

peptide transport [inference]

peptide antigen transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
cytoplasm	NAS	11337487
plasma membrane	TAS
external side of plasma membrane	IBA
membrane	TAS	11337487

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

other organism part [inference]

host cellular component [inference]

host cell

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
virus receptor activity	IDA	15496474 24623090
virus receptor activity	IMP	15496474
protein binding	IPI	32296183 32607506 32766577 33961781 34015061 34341769
D-mannose binding	IBA
carbohydrate binding	NAS	11337487

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

peptide antigen binding

protein binding

exogenous protein binding [inference]

virus receptor activity

carbohydrate binding

monosaccharide binding [inference]

D-mannose binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

monosaccharide binding [inference]

D-mannose binding

peptide binding [inference]

peptide antigen binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

ICAM-3 receptor activity

pattern recognition receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

killer cell lectin-like receptor

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
C-type lectin fold
C-type lectin-like/link domain superfamily
C-type lectin-like

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050598	extrapulmonary tuberculosis	Alliance of Genome Resources
DOID:2945	severe acute respiratory syndrome	Alliance of Genome Resources
DOID:2957	pulmonary tuberculosis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements