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carboxyl ester lipase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

1056

KEGG Gene ID

hsa:1056

PubChem

1056

Alliance of Genome Resources

HGNC:1848

JoGo

CEL

TogoVar

CEL

Annotation

Keyword

3D-structure
Alternative splicing
Diabetes mellitus
Direct protein sequencing
Disulfide bond
Glycoprotein
Lipid degradation
Proteomics identification
Reference proteome
Repeat
Secreted
Serine esterase
Signal

Proteins

Displaying **all 4** entries
UniProt	Protein Name
P19835	Bile salt-stimulated lipase Bucelipase Carboxyl ester lipase Cholesterol esterase Pancreatic lysophospholipase Sterol esterase
O75612
Q86SR3	Bile salt-stimulated lipase Carboxyl ester lipase Cholesterol esterase Pancreatic lysophospholipase Sterol esterase
B4DSX9

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
lipid metabolic process	NAS
cholesterol catabolic process	NAS
lipid catabolic process
cell differentiation	NAS
pancreatic juice secretion	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

lipid catabolic process

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process

alcohol catabolic process [inference]

cholesterol catabolic process

hormone metabolic process [inference]

retinol metabolic process

primary metabolic process [inference]

lipid metabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

steroid metabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol catabolic process

sterol catabolic process [inference]

cholesterol catabolic process

lipid catabolic process

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

alcohol catabolic process [inference]

cholesterol catabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol catabolic process

vitamin metabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process

alcohol catabolic process [inference]

cholesterol catabolic process

olefinic compound metabolic process [inference]

retinol metabolic process

cellular developmental process [inference]

cell differentiation

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

pancreatic juice secretion

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

secretion by tissue [inference]

pancreatic juice secretion

developmental process [inference]

cellular developmental process [inference]

cell differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

pancreatic juice secretion

secretion by tissue [inference]

pancreatic juice secretion

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

regulation of body fluid levels [inference]

body fluid secretion [inference]

pancreatic juice secretion

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GO Term	Evidence Code	PMID
extracellular region	EXP
extracellular region	TAS
extracellular region	IEA
extracellular region	HDA
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
catalytic activity	TAS
sterol ester esterase activity	EXP
sterol ester esterase activity	NAS
sterol ester esterase activity	IBA
sterol ester esterase activity	IEA

GO Hierarchy

molecular function

catalytic activity

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

lipase activity

carboxylic ester hydrolase activity [inference]

short-chain carboxylesterase activity [inference]

acetylesterase activity

retinyl-palmitate esterase activity

binding [inference]

protein binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000170835

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K12298

Name

bile salt-stimulated lipase [EC:3.1.1.3 3.1.1.13]

References

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:0111105	maturity-onset diabetes of the young type 8	Alliance of Genome Resources
DOID:3153	lipomatosis	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000077	Abnormality of the kidney
HP:0000107	Renal cyst
HP:0000112	Nephropathy
HP:0000119	Abnormality of the genitourinary system
HP:0000488	Retinopathy
HP:0000825	Hyperinsulinemic hypoglycemia
HP:0000831	Insulin-resistant diabetes mellitus
HP:0000956	Acanthosis nigricans
HP:0001511	Intrauterine growth retardation