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structural maintenance of chromosomes 2

Summary

Gene Symbol

SMC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10592

KEGG Gene ID

PubChem

10592

Alliance of Genome Resources

HGNC:14011

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cell cycle
Chromosome
Coiled coil
Cytoplasm
DNA condensation
Mitosis
Nucleus
Proteomics identification
Reference proteome

Proteins

Displaying **all 8** entries
UniProt	Protein Name
Q05BV1
A8K984
O95347	Chromosome-associated protein E XCAP-E homolog
B3KMB1
B7ZLZ7
Q6IPS5
Q7Z2X1
Q05D74

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
nuclear division	IEA
mitotic chromosome condensation	TAS
mitotic chromosome condensation	IDA
mitotic chromosome condensation	IBA
mitotic chromosome condensation	IEA

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

immunoglobulin V(D)J recombination [inference]

immunoglobulin heavy chain V-D-J recombination

V(D)J recombination [inference]

immunoglobulin V(D)J recombination [inference]

immunoglobulin heavy chain V-D-J recombination

somatic diversification of immunoglobulins [inference]

somatic recombination of immunoglobulin gene segments [inference]

immunoglobulin V(D)J recombination [inference]

immunoglobulin heavy chain V-D-J recombination

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

immunoglobulin V(D)J recombination [inference]

immunoglobulin heavy chain V-D-J recombination

V(D)J recombination [inference]

immunoglobulin V(D)J recombination [inference]

immunoglobulin heavy chain V-D-J recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments [inference]

immunoglobulin V(D)J recombination [inference]

immunoglobulin heavy chain V-D-J recombination

V(D)J recombination [inference]

immunoglobulin V(D)J recombination [inference]

immunoglobulin heavy chain V-D-J recombination

cell cycle process [inference]

chromosome segregation [inference]

nuclear chromosome segregation

meiotic chromosome segregation

meiotic cell cycle process [inference]

meiotic chromosome segregation

chromosome organization involved in meiotic cell cycle [inference]

meiotic chromosome condensation

mitotic cell cycle process [inference]

mitotic chromosome condensation

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

cell development

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle fission [inference]

nuclear division

chromosome organization

chromosome condensation

kinetochore organization

chromosome organization involved in meiotic cell cycle [inference]

meiotic chromosome condensation

reproductive process [inference]

meiotic cell cycle process [inference]

meiotic chromosome segregation

chromosome organization involved in meiotic cell cycle [inference]

meiotic chromosome condensation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

developmental process [inference]

anatomical structure development [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

cell development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of chromosome condensation

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of chromosome condensation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of chromosome condensation

regulation of chromosome organization [inference]

regulation of chromosome condensation [inference]

positive regulation of chromosome condensation

positive regulation of chromosome organization [inference]

positive regulation of chromosome condensation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of chromosome condensation

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of chromosome segregation [inference]

positive regulation of chromosome segregation

regulation of chromosome separation [inference]

positive regulation of chromosome separation

positive regulation of cell cycle process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
nuclear chromosome	IDA
nuclear chromosome	IEA
chromatin	IBA
condensed chromosome	IDA
condensed chromosome	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

condensin complex

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

nuclear lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

chromosome

nuclear chromosome

condensed nuclear chromosome

condensed chromosome

condensed nuclear chromosome

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

chromosome

nuclear chromosome

condensed nuclear chromosome

condensed chromosome

condensed nuclear chromosome

nucleolus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
chromatin binding	IBA
chromatin binding	IEA
single-stranded DNA binding	IEA
protein binding	IPI
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

single-stranded DNA binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Structural maintenance of chromosome protein

Functional Category

C: Energy production and conversion
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
ATP binding

Displaying **all 6** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
RecF/RecN/SMC, N-terminal
SMCs flexible hinge superfamily
SMCs flexible hinge
Smc2, ATP-binding cassette domain
Structural maintenance of chromosomes protein