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Guidelines

MIRAGE

succinate-CoA ligase ADP-forming subunit beta

Summary

Gene Symbol

SUCLA2

Organism

Apteryx mantelli (North Island brown kiwi)

External Links

NCBI Gene: 106489232
KEGG Gene ID: aam:106489232
PubChem: 106489232

Annotation

Keyword

ATP-binding
Ligase
Magnesium
Metal-binding
Mitochondrion
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A8B7IYH4	ATP-specific succinyl-CoA synthetase subunit beta Succinyl-CoA synthetase beta-A chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
tricarboxylic acid cycle	IEA	22301074 30032202
succinyl-CoA metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

amide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

sulfur compound metabolic process [inference]

thioester metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

primary metabolic process [inference]

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

organic substance metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

thioester metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

sulfur compound metabolic process [inference]

thioester metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine nucleoside bisphosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion	IEA	22301074 30032202
succinate-CoA ligase complex	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

tricarboxylic acid cycle enzyme complex [inference]

succinate-CoA ligase complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
succinate-CoA ligase (ADP-forming) activity	IEA	30032202
ATP binding	IEA	22301074
metal ion binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-sulfur bonds [inference]

acid-thiol ligase activity [inference]

succinate-CoA ligase activity [inference]

succinate-CoA ligase (ADP-forming) activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ligase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 9** entries
Gene Ontology
ATP binding
catalytic activity
ligase activity
magnesium ion binding
metal ion binding
nucleotide binding
succinate-CoA ligase (ADP-forming) activity
succinyl-CoA metabolic process
tricarboxylic acid cycle

Displaying **all 6** entries
InterPro
ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain
ATP-grasp fold, subdomain 1
ATP-grasp fold, succinyl-CoA synthetase-type
Succinate--CoA ligase-like, beta subunit
Succinyl-CoA synthetase, beta subunit, conserved site
Succinyl-CoA synthetase-like

Rhea

succinate + ATP + CoA

phosphate + ADP + succinyl-CoA

Enzyme

6.2.1.5

PMID

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Acknowledgements

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025