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serine hydroxymethyltransferase 2 (mitochondrial)

Summary

Gene Symbol

Shmt2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

108037

KEGG Gene ID

PubChem

108037

Alliance of Genome Resources

MGI:1277989

Gene Ontology (GO)

Displaying entries **1 - 5** of 41 in total

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GO Term	Evidence Code	PMID
regulation of oxidative phosphorylation	ISO
regulation of oxidative phosphorylation	IMP
regulation of oxidative phosphorylation	IEA
glycine metabolic process	ISS
glycine metabolic process	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

tetrahydrofolate interconversion

biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

formate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

tetrahydrofolate interconversion

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K63-linked deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K63-linked deubiquitination

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

proteinogenic amino acid metabolic process [inference]

glycine metabolic process

glycine biosynthetic process

L-serine metabolic process

L-serine biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid metabolic process [inference]

glycine metabolic process

glycine biosynthetic process

L-amino acid metabolic process [inference]

L-serine metabolic process

L-serine biosynthetic process

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K63-linked deubiquitination

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

formate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process

monocarboxylic acid metabolic process [inference]

formate metabolic process [inference]

formate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

formate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

formate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

proteinogenic amino acid metabolic process [inference]

glycine metabolic process

glycine biosynthetic process

L-serine metabolic process

L-serine biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid metabolic process [inference]

glycine metabolic process

glycine biosynthetic process

L-amino acid metabolic process [inference]

L-serine metabolic process

L-serine biosynthetic process

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

one-carbon metabolic process

tetrahydrofolate interconversion

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

formate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization

protein homotetramerization

response to stimulus [inference]

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

response to type I interferon

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of mitochondrial gene expression [inference]

regulation of mitochondrial translation

regulation of generation of precursor metabolites and energy [inference]

regulation of cellular respiration [inference]

regulation of aerobic respiration

regulation of oxidative phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of mitochondrial gene expression [inference]

regulation of mitochondrial translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	ISO
nucleus	IDA
nucleus	IGI
nucleus	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

BRISC complex

cellular anatomical structure [inference]

cytoplasm

nucleoid [inference]

mitochondrial nucleoid

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

mitochondrial nucleoid

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

mitochondrial nucleoid

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
chromatin binding	ISO
chromatin binding	IEA
glycine hydroxymethyltransferase activity	ISS
glycine hydroxymethyltransferase activity	ISO
glycine hydroxymethyltransferase activity	IMP

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

hydroxymethyl-, formyl- and related transferase activity [inference]

glycine hydroxymethyltransferase activity

lyase activity [inference]

carbon-carbon lyase activity [inference]

aldehyde-lyase activity [inference]

threonine aldolase activity [inference]

L-allo-threonine aldolase activity

hydroxytrimethyllysine aldolase activity

binding [inference]

chromatin binding

protein binding [inference]

identical protein binding

amino acid binding

small molecule binding [inference]

vitamin binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

ion binding [inference]

anion binding [inference]

pyridoxal phosphate binding

heterocyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Serine hydroxymethyltransferase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
L-serine catabolic process
cobalt ion binding
folic acid metabolic process
glycine biosynthetic process from serine
glycine hydroxymethyltransferase activity
pyridoxal phosphate binding
serine binding
tetrahydrofolate interconversion
transferase activity
zinc ion binding

Displaying **all 6** entries
InterPro
Pyridoxal phosphate-dependent transferase, major domain
Pyridoxal phosphate-dependent transferase, small domain
Pyridoxal phosphate-dependent transferase
Serine hydroxymethyltransferase, pyridoxal phosphate binding site
Serine hydroxymethyltransferase-like domain
Serine hydroxymethyltransferase