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ectonucleotide pyrophosphatase/phosphodiesterase 3

Summary

Gene Symbol

ENPP3

Organism

Rhinopithecus bieti (black snub-nosed monkey)

External Links

NCBI Gene: 108515701
KEGG Gene ID: rbb:108515701
PubChem: 108515701

Annotation

Keyword

Calcium
Cell membrane
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Reference proteome
Repeat
Secreted
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
A0AAJ7DM45	Alkaline phosphodiesterase I Dinucleoside polyphosphatase Nucleotide diphosphatase Nucleotide pyrophosphatase Phosphodiesterase I beta Phosphodiesterase I/nucleotide pyrophosphatase 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	PMID
basophil activation involved in immune response	IEA	http://purl.obolibrary.org/obo/go/references/0000107
pyrimidine nucleotide metabolic process	IEA	http://purl.obolibrary.org/obo/go/references/0000107
nucleoside triphosphate catabolic process	IEA	30032202 http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000117 http://purl.obolibrary.org/obo/go/references/0000118
negative regulation of mast cell activation involved in immune response	IEA	http://purl.obolibrary.org/obo/go/references/0000107
ATP metabolic process	IEA	http://purl.obolibrary.org/obo/go/references/0000107

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

basophil activation [inference]

basophil activation involved in immune response

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

basophil activation [inference]

basophil activation involved in immune response

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

pyrimidine nucleotide metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

pyrimidine nucleotide metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

pyrimidine nucleotide metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

pyrimidine nucleotide metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleotide metabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

basophil activation [inference]

basophil activation involved in immune response

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

homeostatic process [inference]

chemical homeostasis [inference]

inorganic ion homeostasis [inference]

phosphate ion homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of immune effector process [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of immune response [inference]

negative regulation of mast cell activation involved in immune response

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of mast cell activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of mast cell activation involved in immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of immune response [inference]

negative regulation of mast cell activation involved in immune response

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of intracellular signal transduction [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of immune effector process [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of immune response [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mast cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of immune response [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of intracellular signal transduction [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of inflammatory response [inference]

negative regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of immune response [inference]

negative regulation of mast cell activation involved in immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of immune response [inference]

negative regulation of mast cell activation involved in immune response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of intracellular signal transduction [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mast cell proliferation

regulation of leukocyte proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mast cell proliferation

regulation of mast cell proliferation [inference]

negative regulation of mast cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mast cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of mast cell activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

regulation of mast cell activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation [inference]

negative regulation of mast cell activation involved in immune response

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	http://purl.obolibrary.org/obo/go/references/0000044
external side of plasma membrane	IEA	http://purl.obolibrary.org/obo/go/references/0000107
apical plasma membrane	IEA	http://purl.obolibrary.org/obo/go/references/0000044
perinuclear region of cytoplasm	IEA	http://purl.obolibrary.org/obo/go/references/0000107

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleic acid binding	IEA	22301074 http://purl.obolibrary.org/obo/go/references/0000002
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	IEA	http://purl.obolibrary.org/obo/go/references/0000107
phosphodiesterase I activity	IEA	http://purl.obolibrary.org/obo/go/references/0000003 http://purl.obolibrary.org/obo/go/references/0000107
calcium ion binding	IEA	http://purl.obolibrary.org/obo/go/references/0000107
zinc ion binding	IEA	http://purl.obolibrary.org/obo/go/references/0000107

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

exonuclease activity [inference]

phosphodiesterase I activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phosphodiesterase I activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

bis(5'-nucleosyl)-tetraphosphatase activity [inference]

bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity

cyclic-GMP-AMP hydrolase activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

exonuclease activity [inference]

phosphodiesterase I activity

binding [inference]

nucleic acid binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ectonucleotide pyrophosphatase/phosphodiesterase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
hydrolase activity
metal ion binding

Displaying **all 7** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
DNA/RNA non-specific endonuclease superfamily
DNA/RNA non-specific endonuclease
Extracellular Endonuclease, subunit A
His-Me finger superfamily
Somatomedin B domain
Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase