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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

C-type lectin domain family 12 member B

Summary

Gene Symbol

CLEC12B

Organism

Rhinopithecus bieti (black snub-nosed monkey)

External Links

NCBI Gene: 108517050
KEGG Gene ID: ["rbb:108517050"]
PubChem: 108517050

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Lectin
Phosphoprotein
Receptor
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2K6LTK5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
natural killer cell inhibitory signaling pathway	IEA
negative regulation of natural killer cell mediated cytotoxicity	IEA
melanocyte proliferation	IEA
negative regulation of receptor signaling pathway via STAT	IEA
negative regulation of signaling receptor activity	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-inhibiting signal transduction [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

cell population proliferation [inference]

epithelial cell proliferation [inference]

melanocyte proliferation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of leukocyte mediated immunity [inference]

regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of lymphocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-inhibiting signal transduction [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

regulation of signaling receptor activity [inference]

negative regulation of signaling receptor activity

regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

regulation of signaling receptor activity [inference]

negative regulation of signaling receptor activity

regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via STAT

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-inhibiting signal transduction [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-inhibiting signal transduction [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-inhibiting cell surface receptor signaling pathway [inference]

natural killer cell inhibitory signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

regulation of signaling receptor activity [inference]

negative regulation of signaling receptor activity

regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

regulation of cell killing [inference]

regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

negative regulation of signaling receptor activity

negative regulation of molecular function [inference]

negative regulation of signaling receptor activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IEA
protein-containing complex	IEA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein phosphatase binding	IEA
carbohydrate binding	IEA
signaling receptor regulator activity	IEA
signaling receptor inhibitor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

carbohydrate binding

molecular function regulator activity [inference]

signaling receptor regulator activity

signaling receptor inhibitor activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C-type lectin

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
C-type lectin fold
C-type lectin-like/link domain superfamily
C-type lectin-like

KEGG BRITE Database

Orthology

K17517

Name

C-type lectin domain family 12 member B

References

17562706

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026