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cytochrome P450 family 46 subfamily A member 1

Summary

Gene Symbol

CYP46A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

10858

HGNC

2641

KEGG Gene ID

["hsa:10858"]

PubChem

10858

Alliance of Genome Resources

HGNC:2641

JoGo

CYP46A1

TogoVar

CYP46A1

Annotation

Keyword

3D-structure
Alternative splicing
Cell projection
Cholesterol metabolism
Heme
Microsome
Monooxygenase
Proteomics identification
Reference proteome
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y6A2	Cholesterol 24-monooxygenase Cholesterol 24S-hydroxylase Cytochrome P450 46A1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
bile acid biosynthetic process	TAS
cholesterol catabolic process	ISS
cholesterol catabolic process	TAS
cholesterol catabolic process	IDA
cholesterol catabolic process	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

xenobiotic metabolic process

catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

biosynthetic process [inference]

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

ketone metabolic process [inference]

progesterone metabolic process

hormone metabolic process [inference]

C21-steroid hormone metabolic process

progesterone metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

bile acid metabolic process [inference]

bile acid biosynthetic process

C21-steroid hormone metabolic process

progesterone metabolic process

sterol metabolic process

cholesterol metabolic process [inference]

cholesterol catabolic process

sterol catabolic process [inference]

cholesterol catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol catabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

bile acid metabolic process [inference]

bile acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

olefinic compound metabolic process [inference]

progesterone metabolic process

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to membrane raft

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

protein localization to membrane raft

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to membrane raft

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process

progesterone metabolic process

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	TAS
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IEA
dendrite	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
monooxygenase activity	IEA
iron ion binding	IEA
steroid hydroxylase activity	TAS
steroid hydroxylase activity	IDA
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity

steroid hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

cholesterol 24-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

cholesterol 24-hydroxylase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome p450

Functional Category

C: Energy production and conversion
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

KEGG BRITE Database

Orthology

K07440

Name

cholesterol 24-hydroxylase [EC:1.14.14.25]

References

Rhea

RHEA:22716

O₂ + cholesterol

H₂O + H⁺ + (24S)-hydroxycholesterol

Enzyme

1.14.14.25

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002143
Gene Name: cytochrome P450, family 46, subfamily A, polypeptide 1

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements