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transmembrane p24 trafficking protein 2

Summary

Gene Symbol

TMED2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10959

PubChem

10959

Alliance of Genome Resources

HGNC:16996

JoGo

TMED2

TogoVar

TMED2

Annotation

Keyword

3D-structure
Coiled coil
Cytoplasmic vesicle
ER-Golgi transport
Endoplasmic reticulum
Golgi apparatus
Protein transport
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q15363	Membrane protein p24A p24 p24 family protein beta-1
Q6FHT8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 33 in total

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GO Term	Evidence Code	PMID
neural tube closure
maternal placenta development	IEA	http://purl.obolibrary.org/obo/go/references/0000107
heart looping
intracellular protein transport	IDA	20427317
intracellular protein transport	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

PERK-mediated unfolded protein response

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

intracellular signaling cassette [inference]

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

intercellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular localization [inference]

intracellular transport [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

maintenance of protein localization in organelle

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

Golgi organization

vesicle organization [inference]

vesicle coating [inference]

Golgi transport vesicle coating [inference]

COPI coating of Golgi vesicle

COPII vesicle coating

cellular component assembly [inference]

protein-containing complex assembly [inference]

COPII vesicle coating

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

COPII vesicle coating

membrane organization [inference]

endoplasmic reticulum membrane organization

export from cell [inference]

secretion by cell [inference]

protein secretion

reproductive process [inference]

developmental process involved in reproduction [inference]

maternal placenta development

multicellular organismal reproductive process [inference]

maternal process involved in female pregnancy [inference]

maternal placenta development

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching involved in labyrinthine layer morphogenesis

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation [inference]

dorsal/ventral neural tube patterning

axis specification [inference]

embryonic axis specification [inference]

somite rostral/caudal axis specification

anterior/posterior axis specification [inference]

somite rostral/caudal axis specification

embryonic pattern specification [inference]

embryonic axis specification [inference]

somite rostral/caudal axis specification

multicellular organism growth

developmental process [inference]

developmental process involved in reproduction [inference]

maternal placenta development

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching involved in labyrinthine layer morphogenesis

tube morphogenesis [inference]

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

post-anal tail morphogenesis

embryonic morphogenesis

embryonic heart tube morphogenesis [inference]

heart looping

branching involved in labyrinthine layer morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

morphogenesis of a branching epithelium [inference]

branching involved in labyrinthine layer morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

blood vessel development [inference]

placenta blood vessel development [inference]

labyrinthine layer blood vessel development

maternal placenta development

animal organ development [inference]

embryonic organ development [inference]

labyrinthine layer blood vessel development

extraembryonic membrane development [inference]

growth [inference]

developmental growth [inference]

multicellular organism growth

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

protein transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

vesicle cargo loading

secretion [inference]

secretion by cell [inference]

protein secretion

intracellular transport [inference]

export from cell [inference]

secretion by cell [inference]

protein secretion

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of localization in cell [inference]

intracellular transport [inference]

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in cell [inference]

maintenance of protein localization in organelle

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

maintenance of protein localization in organelle

cellular localization [inference]

intracellular transport [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of intracellular signal transduction [inference]

regulation of SREBP signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of transport [inference]

regulation of intracellular transport [inference]

regulation of cargo loading into COPII-coated vesicle

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of cargo loading into COPII-coated vesicle

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of GTPase activity

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of intracellular signal transduction [inference]

regulation of SREBP signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of SREBP signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

PERK-mediated unfolded protein response

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

intracellular signaling cassette [inference]

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of intracellular signal transduction [inference]

regulation of SREBP signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of cargo loading into COPII-coated vesicle

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular response to stress [inference]

regulation of SREBP signaling pathway

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

negative regulation of GTPase activity

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS	https://reactome.org/content/detail/R-HSA-6809006 https://reactome.org/content/detail/R-HSA-6809010 https://reactome.org/content/detail/R-HSA-6809011 https://reactome.org/content/detail/R-HSA-6811417 https://reactome.org/content/detail/R-HSA-6811418
endoplasmic reticulum	IDA	12237308 30540941
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	EXP	10852829 12237308
endoplasmic reticulum membrane	TAS	https://reactome.org/content/detail/R-HSA-203973 https://reactome.org/content/detail/R-HSA-204008 https://reactome.org/content/detail/R-HSA-5694410 https://reactome.org/content/detail/R-HSA-5694417 https://reactome.org/content/detail/R-HSA-5694522 https://reactome.org/content/detail/R-HSA-5694527 https://reactome.org/content/detail/R-HSA-6811423 https://reactome.org/content/detail/R-HSA-6811427

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

Golgi-associated vesicle membrane [inference]

COPI-coated vesicle membrane

coated vesicle membrane [inference]

secretory granule membrane [inference]

zymogen granule membrane

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

Golgi-associated vesicle membrane [inference]

COPI-coated vesicle membrane

coated vesicle membrane [inference]

secretory granule membrane [inference]

zymogen granule membrane

endoplasmic reticulum-Golgi intermediate compartment membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

COPI-coated vesicle

transport vesicle

coated vesicle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

COPI-coated vesicle

transport vesicle

coated vesicle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

COPI-coated vesicle

transport vesicle

coated vesicle [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
frizzled binding	IEA	http://purl.obolibrary.org/obo/go/references/0000107
smoothened binding	IEA	http://purl.obolibrary.org/obo/go/references/0000107
protein binding	IPI	10359607 12237308 17693410 18287528 20361938 20427317 21219331 30540941 31040128 33961781 35271311 40205054