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histocompatibility 2, Q region locus 6

Summary

Gene Symbol

H2-Q6

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

110557

PubChem

110557

Alliance of Genome Resources

MGI:95935

Annotation

Keyword

Glycoprotein
MHC I
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P79568

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
positive regulation of T cell mediated cytotoxicity	IBA
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA
immune response	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response

antigen processing and presentation [inference]

antigen processing and presentation via MHC class Ib [inference]

antigen processing and presentation of peptide antigen via MHC class Ib [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous antigen [inference]

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of peptide antigen via MHC class Ib [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen via MHC class I [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of leukocyte mediated immunity [inference]

regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of cellular process [inference]

regulation of cell killing [inference]

regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
Golgi membrane	ISO
extracellular space	IBA
lysosomal membrane	ISO
early endosome	ISO
endoplasmic reticulum	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

MHC class I peptide loading complex

plasma membrane protein complex [inference]

MHC protein complex [inference]

endoplasmic reticulum protein-containing complex [inference]

MHC class I peptide loading complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

early endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

cis-Golgi network membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi cisterna [inference]

Golgi medial cisterna

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

endoplasmic reticulum exit site

side of membrane [inference]

external side of plasma membrane

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	ISO
signaling receptor binding	IBA
beta-2-microglobulin binding	ISO
peptide binding	ISO
MHC class I protein binding	ISO

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

peptide antigen binding

protein binding [inference]

signaling receptor binding

MHC protein binding [inference]

MHC class I protein binding

beta-2-microglobulin binding

identical protein binding

protein homodimerization activity

TAP binding

protein dimerization activity [inference]

protein homodimerization activity

amide binding [inference]

peptide binding

peptide antigen binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

H-2 class I histocompatibility antigen, alpha chain

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
antigen processing and presentation of peptide antigen via MHC class I
immune response
positive regulation of T cell mediated cytotoxicity
signaling receptor binding

Displaying **all 4** entries
InterPro
Immunoglobulin C1-set
MHC class I-like antigen recognition-like superfamily
MHC class I-like antigen recognition-like
MHC classes I/II-like antigen recognition protein