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sodium channel, voltage-gated, type II, alpha

Summary

Gene Symbol

Scn2a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

110876

PubChem

110876

Alliance of Genome Resources

MGI:98248

Annotation

Keyword

Cell membrane
Coiled coil
Disulfide bond
Glycoprotein
Isopeptide bond
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Sodium channel
Transmembrane helix
Ubl conjugation
Voltage-gated channel

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A5H1ZRM8
B1AWN6	Voltage-gated sodium channel subunit alpha Nav1.2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
sodium ion transport	ISO
sodium ion transport	IDA	10827969
nervous system development	IMP	10827969
memory	IMP	29867081
determination of adult lifespan	IGI	21156207

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory

behavior [inference]

learning or memory [inference]

memory

determination of adult lifespan

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

response to osmotic stress [inference]

cellular response to osmotic stress [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

cellular response to hypoxia

response to abiotic stimulus [inference]

response to osmotic stress [inference]

cellular response to osmotic stress [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to osmotic stress

regulation of biological quality [inference]

regulation of membrane potential [inference]

action potential [inference]

neuronal action potential

membrane depolarization [inference]

membrane depolarization during action potential

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
voltage-gated sodium channel complex	ISO
voltage-gated sodium channel complex	TAS	10827969
voltage-gated sodium channel complex	IBA
plasma membrane	ISO
plasma membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated sodium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

axon initial segment

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
voltage-gated sodium channel activity	ISO
voltage-gated sodium channel activity	IDA	10827969
voltage-gated sodium channel activity	IMP	10827969
voltage-gated sodium channel activity	IBA
sodium channel activity	TAS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation channel activity [inference]

sodium channel activity

voltage-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity

voltage-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

voltage-gated sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

voltage-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation channel activity [inference]

sodium channel activity

voltage-gated sodium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

voltage-gated sodium channel activity

binding [inference]

protein binding [inference]

calmodulin binding

protein domain specific binding [inference]

LRR domain binding [inference]

leucine zipper domain binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

alkali metal ion binding [inference]

sodium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sodium channel protein

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
membrane depolarization during action potential
monoatomic ion channel activity
monoatomic ion transport
neuronal action potential
sodium ion transmembrane transport
voltage-gated sodium channel activity

Displaying **all 3** entries
InterPro
Ion transport domain
Voltage-dependent channel domain superfamily
Voltage-gated cation channel calcium and sodium

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources

Ortholog

Displaying entries **131 - 134** of **134** in total

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Species	Gene ID	Orthologous MAtrix
Strigops habroptila	115609095	STRHB03655
Corvus moneduloides	116446484	CORMO24947
Rhinolophus ferrumequinum	117025712	RHIFE13670
Balaenoptera musculus	118898148	BALMU00283