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solute carrier family 8 (sodium/calcium exchanger), member 3

Summary

Gene Symbol

Slc8a3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

110893

KEGG Gene ID

PubChem

110893

Alliance of Genome Resources

MGI:107976

Annotation

Keyword

3D-structure
Alternative splicing
Antiport
Calcium transport
Calmodulin-binding
Cell junction
Cell membrane
Cell projection
Cytoplasm
Endoplasmic reticulum
Glycoprotein
Metal-binding
Mitochondrion outer membrane
Proteomics identification
Reference proteome
Repeat
Signal
Sodium transport
Synapse
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
S4R2P9	Na(+)/Ca(2+)-exchange protein 3 Solute carrier family 8 member 3
Q8BXN1
E9PX50
Q3UTP5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 43 in total

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GO Term	Evidence Code	PMID
hematopoietic progenitor cell differentiation	IMP
sodium ion transport	ISO
sodium ion transport	IEA
calcium ion transport	IEA
mitochondrial calcium ion transmembrane transport	IMP

GO Hierarchy

biological process

cellular process [inference]

cell communication

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

glial cell differentiation [inference]

oligodendrocyte differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

mitochondrial calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion export across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

export across plasma membrane [inference]

calcium ion export across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization

export from cell [inference]

export across plasma membrane [inference]

calcium ion export across plasma membrane

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

developmental process [inference]

anatomical structure development [inference]

telencephalon development

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

glial cell differentiation [inference]

oligodendrocyte differentiation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

mitochondrial calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

mitochondrial calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

mitochondrial calcium ion homeostasis

calcium ion homeostasis

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

mitochondrial calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

mitochondrial calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

mitochondrial calcium ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to stress [inference]

cellular response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to chemical [inference]

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

response to nitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to cAMP

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport

sodium ion transport

sodium ion transmembrane transport

calcium ion transport

calcium ion import [inference]

calcium ion import across plasma membrane

calcium ion transmembrane transport

mitochondrial calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion export across plasma membrane

calcium ion import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

mitochondrial calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion export across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

mitochondrial calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion export across plasma membrane

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

mitochondrial calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion export across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

export across plasma membrane [inference]

calcium ion export across plasma membrane

import into cell [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

calcium ion export across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

modulation of excitatory postsynaptic potential

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

modulation of excitatory postsynaptic potential

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

modulation of excitatory postsynaptic potential

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

modulation of excitatory postsynaptic potential

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

modulation of excitatory postsynaptic potential

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of multicellular organismal process [inference]

regulation of system process

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of skeletal muscle contraction

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration [inference]

calcium ion transport into cytosol

regulation of membrane potential [inference]

modulation of excitatory postsynaptic potential

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

Displaying entries **1 - 5** of 55 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	ISO
nucleoplasm	ISO
mitochondrial outer membrane	ISO
mitochondrial outer membrane	IDA
mitochondrial outer membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

nucleoplasm

cytoplasm [inference]

sarcoplasm

microtubule organizing center [inference]

centrosome

cytosol

membrane

plasma membrane

sarcolemma

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

neuromuscular junction

anchoring junction

cell projection

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

perikaryon

organelle

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

postsynapse

dendritic spine

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
calcium:sodium antiporter activity	ISO
calcium:sodium antiporter activity	IMP
calcium:sodium antiporter activity	IBA
calcium:sodium antiporter activity	IEA
calmodulin binding

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium:monoatomic cation antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity

binding [inference]

protein binding [inference]

calmodulin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SODIUM/CALCIUM EXCHANGER

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium ion transport
calcium
calmodulin binding
cell communication
metal ion binding
monoatomic ion transport
sodium ion transmembrane transport

Displaying **all 6** entries
InterPro
CalX-like domain superfamily
NCX, central ion-binding domain superfamily
Na-Ca exchanger/integrin-beta4
Sodium/calcium exchanger domain, C-terminal extension
Sodium/calcium exchanger membrane region
Sodium/calcium exchanger protein

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	140448	RGD:620197
Drosophila melanogaster	42481	FB:FBgn0013995
Homo sapiens	6547	HGNC:11070

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements