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chitinase 1

Summary

Gene Symbol

CHIT1

Aliases

CHI3
CHIT
chitotriosidase

Organism

Homo sapiens (human)

External Links

NCBI Gene

1118

HGNC

1936

KEGG Gene ID

hsa:1118

PubChem

1118

Alliance of Genome Resources

HGNC:1936

Annotation

Keyword

3D-structure
Alternative splicing
Chitin degradation
Chitin-binding
Direct protein sequencing
Disulfide bond
Glycoprotein
Glycosidase
Lysosome
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13231	Chitinase-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
polysaccharide catabolic process	IEA
chitin catabolic process	TAS	9748235
chitin catabolic process	IDA	19725875
chitin catabolic process	IBA
immune response	NAS	9748235

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process

aminoglycan catabolic process [inference]

chitin catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process [inference]

chitin catabolic process

macromolecule catabolic process [inference]

polysaccharide catabolic process

aminoglycan catabolic process [inference]

chitin catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process [inference]

chitin catabolic process

amino sugar metabolic process [inference]

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

glucosamine-containing compound metabolic process [inference]

chitin metabolic process [inference]

chitin catabolic process

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process

aminoglycan catabolic process [inference]

chitin catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

multicellular organismal process [inference]

digestion [inference]

polysaccharide digestion

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IBA
extracellular space	IDA	19725875
lysosome	IEA
specific granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

tertiary granule lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
hydrolase activity, hydrolyzing O-glycosyl compounds	TAS
chitinase activity	TAS	9748235
chitinase activity	IDA	11085997
chitinase activity	IBA
protein binding	IPI	33961781

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

chitinase activity

endochitinase activity

binding [inference]

protein binding

carbohydrate derivative binding [inference]

chitin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

chitinase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
chitin binding
chitin catabolic process
chitinase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity

Displaying **all 5** entries
InterPro
Chitinase II
Chitinase insertion domain superfamily
Glycoside hydrolase family 18, catalytic domain
Glycoside hydrolase superfamily
Glycosyl hydrolases family 18 (GH18) active site

KEGG BRITE Database

Orthology

K01183

Name

chitinase [EC:3.2.1.14]

References

Disease

PubChem Disease

MedGen Diseases

Chitotriosidase deficiency

OMIM Phenotypes

CHITOTRIOSIDASE DEFICIENCY; CHITD

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **11 - 20** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	34979	ZFIN:ZDB-GENE-040426-1994
Danio rerio	34981	ZFIN:ZDB-GENE-040426-1994
Danio rerio	36868	ZFIN:ZDB-GENE-040426-1994
Danio rerio	37104	ZFIN:ZDB-GENE-040426-1994
Danio rerio	38223	ZFIN:ZDB-GENE-040426-1994
Mus musculus	71884	ZFIN:ZDB-GENE-040426-1994	MOUSE29398
Saccharomyces cerevisiae S288C	81600	SGD:S000002779
Saccharomyces cerevisiae S288C	89824	SGD:S000002779
Saccharomyces cerevisiae S288C	104183	SGD:S000002779
Saccharomyces cerevisiae S288C	113901	SGD:S000002779

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements