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choline kinase beta

Summary

Gene Symbol

CHKB

Aliases

CHETK

Organism

Homo sapiens (human)

External Links

NCBI Gene

1120

HGNC

1938

KEGG Gene ID

["hsa:1120"]

PubChem

1120

Alliance of Genome Resources

HGNC:1938

JoGo

CHKB

TogoVar

CHKB

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Congenital muscular dystrophy
Direct protein sequencing
Disease variant
Kinase
Phospholipid biosynthesis
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y259	Choline kinase beta Choline kinase-like protein Ethanolamine kinase Ethanolamine kinase beta choline/ethanolamine kinase beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
phosphatidylethanolamine biosynthetic process	IDA
phosphatidylethanolamine biosynthetic process	IBA
phosphatidylethanolamine biosynthetic process	IEA
CDP-choline pathway	IBA
muscle organ development

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

muscle organ development

muscle structure development [inference]

muscle organ development

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

Displaying entries **1 - 5** of 8 in total

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2

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GO Term	Evidence Code	PMID
choline kinase activity	EXP
choline kinase activity	IDA
choline kinase activity	IBA
choline kinase activity	IEA
ethanolamine kinase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

phosphotransferase activity, alcohol group as acceptor [inference]

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

choline kinase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
choline kinase activity
ethanolamine kinase activity
kinase activity
phosphatidylethanolamine biosynthetic process
phosphorylation

Displaying 1 entry
InterPro
Protein kinase-like domain superfamily

Human Protein Atlas

ENSG00000100288

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K14156

Name

choline/ethanolamine kinase [EC:2.7.1.32 2.7.1.82]

References

Rhea

RHEA:13069

ATP + ethanolamine

H⁺ + ADP + phosphoethanolamine

Enzyme

2.7.1.82

PMID

RHEA:12837

choline + ATP

H⁺ + phosphocholine + ADP

Enzyme

2.7.1.32

PMID

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0110632	megaconial type congenital muscular dystrophy	Alliance of Genome Resources
DOID:1059	intellectual disability	Alliance of Genome Resources
DOID:8619	recurrent hypersomnia	Alliance of Genome Resources
DOID:8986	narcolepsy	Alliance of Genome Resources
DOID:9884	muscular dystrophy	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 20 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000750	Delayed speech and language development
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001270	Motor delay
HP:0001290	Generalized hypotonia
HP:0001324	Muscle weakness
HP:0001644	Dilated cardiomyopathy
HP:0002465	Poor speech