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egl-9 family hypoxia-inducible factor 2

Summary

Gene Symbol

Egln2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

112406

KEGG Gene ID

PubChem

112406

Alliance of Genome Resources

MGI:1932287

Annotation

Keyword

Dioxygenase
Iron
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation
Vitamin C

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q80X29
Q91YE2	Egl nine homolog 2 Falkor Hypoxia-inducible factor prolyl hydroxylase 1 Prolyl hydroxylase domain-containing protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
response to hypoxia	ISS
response to hypoxia	ISO
response to hypoxia	IEA
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	ISS
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

modified amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

macromolecule modification [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

primary metabolic process [inference]

amino acid metabolic process [inference]

non-proteinogenic amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

non-proteinogenic amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia

cellular response to hypoxia

cellular response to stress [inference]

cellular response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of cellular process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	ISO
nucleus	IBA
nucleus	IEA
nucleoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
iron ion binding	IEA
ferrous iron binding	ISS
ferrous iron binding	ISO
ferrous iron binding	IBA
ferrous iron binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

2-oxoglutarate-dependent dioxygenase activity

peptidyl-proline dioxygenase activity [inference]

peptidyl-proline 4-dioxygenase activity

hypoxia-inducible factor-proline dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity

peptidyl-proline dioxygenase activity [inference]

peptidyl-proline 4-dioxygenase activity

hypoxia-inducible factor-proline dioxygenase activity

catalytic activity, acting on a protein [inference]

peptidyl-proline dioxygenase activity [inference]

peptidyl-proline 4-dioxygenase activity

hypoxia-inducible factor-proline dioxygenase activity

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

ferrous iron binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

molecular function regulator activity [inference]

molecular sensor activity [inference]

oxygen sensor activity

Gene Ontology information from NCBI Gene and UniProt.

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Last updated: April 6, 2026

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