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cholinergic receptor muscarinic 1

Summary

Gene Symbol

CHRM1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1128

PubChem

1128

Alliance of Genome Resources

HGNC:1950

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q53XZ3
P11229

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
signal transduction	TAS	1411529
G protein-coupled receptor signaling pathway	TAS	7925360
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA
phospholipase C-activating G protein-coupled receptor signaling pathway	TAS	9603968

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

saliva secretion

nervous system process [inference]

cognition

secretion by tissue [inference]

saliva secretion

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

saliva secretion

secretion by tissue [inference]

saliva secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

regulation of monoatomic ion transport [inference]

positive regulation of ion transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of ion transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of locomotion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of ion transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

regulation of cell population proliferation [inference]

regulation of glial cell proliferation

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential

regulation of body fluid levels [inference]

body fluid secretion [inference]

saliva secretion

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IBA
membrane	TAS	7925360
dendrite	IBA
presynaptic membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phosphatidylinositol phospholipase C activity	TAS	9614217
G protein-coupled serotonin receptor activity
protein binding	IPI	21056967
G protein-coupled acetylcholine receptor activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled acetylcholine receptor activity

acetylcholine receptor activity [inference]

G protein-coupled acetylcholine receptor activity

neurotransmitter receptor activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

acetylcholine receptor activity [inference]

G protein-coupled acetylcholine receptor activity

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled acetylcholine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5-hydroxytryptamine receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050214	Lambert-Eaton myasthenic syndrome	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:437	myasthenia gravis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 61 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1128	Xenbase:XB-GENE-22061118
Drosophila melanogaster	1129	FB:FBgn0000037
Drosophila melanogaster	1131	FB:FBgn0000037
Drosophila melanogaster	1132	FB:FBgn0000037
Drosophila melanogaster	1133	FB:FBgn0000037
Mus musculus	12669	Xenbase:XB-GENE-22061118	MOUSE25785
Drosophila melanogaster	12671	FB:FBgn0000037
Drosophila melanogaster	12672	FB:FBgn0000037
Drosophila melanogaster	24260	FB:FBgn0000037
Drosophila melanogaster	25111	FB:FBgn0000037