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Guidelines

MIRAGE

ATP-binding cassette, sub-family A member 4

Summary

Gene Symbol

Abca4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11304

KEGG Gene ID

[""]

PubChem

11304

Alliance of Genome Resources

MGI:109424

Annotation

Keyword

ATP-binding
Cell projection
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Hydrolase
Magnesium
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix
Transport
Vision

Proteins

Displaying 1 entry
UniProt	Protein Name
O35600	ATP-binding cassette sub-family A member 4 RIM ABC transporter Retinal-specific ATP-binding cassette transporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
retinoid metabolic process	ISS
phospholipid transfer to membrane	IMP
lipid transport	IBA
lipid transport	IEA
visual perception	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process [inference]

retinal metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinal metabolic process

olefinic compound metabolic process [inference]

retinal metabolic process

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation

phospholipid translocation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

photoreceptor cell maintenance

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport

phospholipid transport [inference]

lipid translocation

phospholipid translocation

organophosphate ester transport [inference]

phospholipid transport [inference]

transmembrane transport

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation

phospholipid translocation

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
photoreceptor outer segment	IDA
photoreceptor outer segment	IEA
endoplasmic reticulum	ISS
endoplasmic reticulum	ISO
endoplasmic reticulum	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

photoreceptor outer segment

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

rod photoreceptor disc membrane

photoreceptor disc membrane [inference]

rod photoreceptor disc membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
GTPase activity	ISS
retinoid binding	ISS
11-cis retinal binding	ISS
11-cis retinal binding	ISO
11-cis retinal binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

transporter activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

intramembrane lipid carrier activity [inference]

ATPase-coupled intramembrane lipid carrier activity

flippase activity

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

N-retinylidene-phosphatidylethanolamine flippase activity

binding [inference]

lipid binding [inference]

isoprenoid binding [inference]

retinoid binding

retinal binding [inference]

small molecule binding [inference]

vitamin binding [inference]

retinal binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular carrier activity [inference]

lipid carrier activity [inference]

intramembrane lipid carrier activity [inference]

ATPase-coupled intramembrane lipid carrier activity

flippase activity

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

N-retinylidene-phosphatidylethanolamine flippase activity

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ATPase-coupled intramembrane lipid carrier activity

flippase activity

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

N-retinylidene-phosphatidylethanolamine flippase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atp-binding cassette sub-family a

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter A
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
ABC-2 type transporter, transmembrane domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050817	Stargardt disease	Alliance of Genome Resources
DOID:0110354	retinitis pigmentosa 19	Alliance of Genome Resources
DOID:0111013	cone-rod dystrophy 3	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026