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Guidelines

MIRAGE

U2 small nuclear RNA auxiliary factor 2

Summary

Gene Symbol

U2AF2

Organism

Homo sapiens (human)

External Links

NCBI Gene

11338

KEGG Gene ID

PubChem

11338

Alliance of Genome Resources

HGNC:23156

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Direct protein sequencing
Disease variant
Hydroxylation
Intellectual disability
Isopeptide bond
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Repeat
Repressor
Spliceosome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P26368	U2 auxiliary factor 65 kDa subunit U2 snRNP auxiliary factor large subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
spliceosomal complex assembly	IBA
mRNA splicing, via spliceosome	NAS
mRNA splicing, via spliceosome	IC
mRNA splicing, via spliceosome	IDA
mRNA processing	TAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

spliceosomal complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

spliceosomal complex assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

spliceosomal complex assembly

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination

negative regulation of RNA metabolic process [inference]

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

negative regulation of gene expression [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

regulation of RNA splicing [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

positive regulation of RNA splicing

regulation of mRNA splicing, via spliceosome [inference]

negative regulation of mRNA splicing, via spliceosome

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination

negative regulation of RNA metabolic process [inference]

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

negative regulation of gene expression [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

regulation of RNA splicing [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

positive regulation of RNA splicing

regulation of mRNA splicing, via spliceosome [inference]

negative regulation of mRNA splicing, via spliceosome

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination

negative regulation of RNA metabolic process [inference]

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

negative regulation of protein ubiquitination

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA splicing, via spliceosome [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA splicing, via spliceosome [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

regulation of RNA splicing [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

positive regulation of RNA splicing

regulation of mRNA splicing, via spliceosome [inference]

negative regulation of mRNA splicing, via spliceosome

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

negative regulation of protein ubiquitination

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination

negative regulation of RNA metabolic process [inference]

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA processing [inference]

negative regulation of mRNA splicing, via spliceosome

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
commitment complex	IBA
Prp19 complex	IDA
nucleus	NAS
nucleus	IDA
nucleus	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

Prp19 complex

nuclear protein-containing complex [inference]

spliceosomal complex

U2-type spliceosomal complex [inference]

prespliceosome [inference]

U2-type prespliceosome

U2AF complex

ribonucleoprotein complex [inference]

spliceosomal complex

U2-type spliceosomal complex [inference]

prespliceosome [inference]

U2-type prespliceosome

cellular anatomical structure [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

supramolecular complex [inference]

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleic acid binding	IEA
RNA binding	IEA
RNA binding	HDA
protein binding	IPI
poly-pyrimidine tract binding	IBA

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding

single-stranded RNA binding [inference]

poly-pyrimidine tract binding

pre-mRNA binding [inference]

pre-mRNA 3'-splice site binding

protein binding

enzyme binding

protein domain specific binding [inference]

C2H2 zinc finger domain binding

molecular function regulator activity [inference]

molecular function inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

splicing factor U2AF

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
mRNA processing
poly-pyrimidine tract binding
pre-mRNA 3'-splice site binding

Displaying **all 4** entries
InterPro
Nucleotide-binding alpha-beta plait domain superfamily
RNA recognition motif domain
RNA-binding domain superfamily
U2 snRNP auxilliary factor, large subunit, splicing factor

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060933	developmental delay, dysmorphic facies, and brain anomalies	Alliance of Genome Resources

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	22185	MGI:98886

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026