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exosome component 8

Summary

Gene Symbol

EXOSC8

Organism

Homo sapiens (human)

External Links

NCBI Gene

11340

KEGG Gene ID

PubChem

11340

Alliance of Genome Resources

HGNC:17035

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Disease variant
Exosome
Neurodegeneration
Nucleus
Proteomics identification
RNA-binding
Reference proteome
rRNA processing

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96B26	Exosome component 8 Opa-interacting protein 2 Ribosomal RNA-processing protein 43 p9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
RNA processing	IDA
RNA processing	IEA
RNA catabolic process	IDA
RNA catabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

rRNA catabolic process

snRNA metabolic process [inference]

snRNA processing [inference]

snRNA 3'-end processing [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

rRNA catabolic process

snRNA metabolic process [inference]

snRNA processing [inference]

snRNA 3'-end processing [inference]

nucleic acid catabolic process [inference]

RNA catabolic process

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

rRNA catabolic process

tRNA decay [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA surveillance [inference]

nuclear RNA surveillance [inference]

tRNA surveillance [inference]

TRAMP-dependent tRNA surveillance pathway

RNA processing

rRNA processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snRNA processing [inference]

snRNA 3'-end processing [inference]

RNA 3'-end processing [inference]

rRNA 3'-end processing [inference]

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snRNA 3'-end processing [inference]

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear mRNA surveillance

Displaying entries **6 - 10** of 22 in total

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GO Term	Evidence Code	PMID
exosome (RNase complex)	IDA
exosome (RNase complex)	IEA
fibrillar center	IDA
nucleus	IDA
nucleus	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear exosome (RNase complex)

nucleolar exosome (RNase complex)

catalytic complex [inference]

exoribonuclease complex

exosome (RNase complex)

nuclear exosome (RNase complex)

nucleolar exosome (RNase complex)

cytoplasmic exosome (RNase complex)

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
RNA exonuclease activity	IDA
protein binding	IPI
mRNA 3'-UTR AU-rich region binding	IDA
mRNA 3'-UTR AU-rich region binding	IBA
identical protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

exonuclease activity [inference]

RNA exonuclease activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

exonuclease activity [inference]

RNA exonuclease activity

RNA nuclease activity [inference]

RNA exonuclease activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA exonuclease activity

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

mRNA binding [inference]

mRNA 3'-UTR binding [inference]

mRNA 3'-UTR AU-rich region binding

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112334	pontocerebellar hypoplasia type 1C	Alliance of Genome Resources

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026

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