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A-kinase anchoring protein 1

Summary

Gene Symbol

Akap1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

114124

KEGG Gene ID

PubChem

114124

Alliance of Genome Resources

RGD:620826

Annotation

Keyword

Alternative splicing
Kinase
Mitochondrion outer membrane
Phosphoprotein
RNA-binding
Reference proteome
Transit peptide
Transmembrane
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A6HHY9
F1LMK0
A6HHY7	Dual specificity A-kinase-anchoring protein 1 Protein kinase A-anchoring protein 1
D4A9M6
O88884	A-kinase anchor protein 121 kDa Dual specificity A-kinase-anchoring protein 1 Protein kinase A-anchoring protein 1 Spermatid A-kinase anchor protein 84

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
apoptotic process	ISS
apoptotic process	ISO
protein localization	ISO
intracellular protein localization	ISO
obsolete regulation of protein kinase A signaling

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response [inference]

antiviral innate immune response

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

antiviral innate immune response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antiviral innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to virus [inference]

antiviral innate immune response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antiviral innate immune response

immune response [inference]

innate immune response [inference]

antiviral innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

antiviral innate immune response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antiviral innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

antiviral innate immune response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antiviral innate immune response

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

response to chemical [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

response to nitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

response to cAMP [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

localization [inference]

macromolecule localization [inference]

intracellular protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization to nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization to nucleus [inference]

negative regulation of protein import into nucleus

regulation of transport [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of developmental growth [inference]

regulation of organ growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle process involved in oocyte maturation

positive regulation of cell cycle process [inference]

positive regulation of meiotic cell cycle process involved in oocyte maturation

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle process involved in oocyte maturation

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

negative regulation of cell growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of multicellular organismal process [inference]

negative regulation of muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization to nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of response to stimulus [inference]

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of striated muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of developmental growth [inference]

regulation of organ growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

regulation of dephosphorylation [inference]

negative regulation of dephosphorylation

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of striated muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cell growth involved in cardiac muscle cell development

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle process involved in oocyte maturation

positive regulation of cell cycle process [inference]

positive regulation of meiotic cell cycle process involved in oocyte maturation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

negative regulation of cell growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

positive regulation of cell cycle process [inference]

positive regulation of meiotic cell cycle process involved in oocyte maturation

regulation of meiotic cell cycle process involved in oocyte maturation [inference]

positive regulation of meiotic cell cycle process involved in oocyte maturation

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle process involved in oocyte maturation

positive regulation of cell cycle process [inference]

positive regulation of meiotic cell cycle process involved in oocyte maturation

regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle process involved in oocyte maturation

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle hypertrophy [inference]

regulation of cardiac muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of organ growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of multicellular organismal process [inference]

negative regulation of muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of cell growth involved in cardiac muscle cell development [inference]

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cell growth involved in cardiac muscle cell development

regulation of reproductive process [inference]

regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle process involved in oocyte maturation

regulation of meiotic cell cycle process involved in oocyte maturation [inference]

positive regulation of meiotic cell cycle process involved in oocyte maturation

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle process involved in oocyte maturation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISO
mitochondrion	ISS
mitochondrion	ISO
mitochondrion	IBA
mitochondrion	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse [inference]

neuromuscular junction

mitochondrial crista

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

membraneless organelle [inference]

intracellular membraneless organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular membraneless organelle [inference]

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleic acid binding	IEA
RNA binding	IEA
microtubule binding	IDA
kinase activity
protein kinase binding	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

binding [inference]

nucleic acid binding

RNA binding

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

phosphatase binding [inference]

protein phosphatase binding

protein kinase A binding [inference]

protein kinase A regulatory subunit binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

a kinase anchor protein

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
protein kinase A regulatory subunit binding

Displaying **all 7** entries
InterPro
A-kinase anchor protein 1, Tudor domain
A-kinase anchor protein 1, type I K homology domain
K Homology domain, type 1 superfamily
K Homology domain, type 1
K Homology domain
SNase-like, OB-fold superfamily
Tudor domain

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
neuromuscular junction	PMID:11716788
lipid droplet	PMID:16756943
mitochondrial crista	PMID:16996504
postsynaptic membrane	PMID:11716788

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11640	MGI:104729
Homo sapiens	8165	HGNC:367

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements