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Guidelines

MIRAGE

angiotensin I converting enzyme

Summary

Gene Symbol

Ace

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11421

PubChem

11421

Alliance of Genome Resources

MGI:87874

Annotation

Keyword

Alternative promoter usage
Calmodulin-binding
Carboxypeptidase
Cell membrane
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3TU20
P09470	Dipeptidyl carboxypeptidase I Kininase II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 72 in total

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GO Term	Evidence Code	PMID
kidney development	ISO
kidney development	IMP
kidney development	IEA
angiotensin maturation	ISO
angiotensin maturation	IDA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

myeloid leukocyte mediated immunity [inference]

neutrophil mediated immunity

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway

metabolic process [inference]

peptide metabolic process

peptide catabolic process

neuropeptide catabolic process [inference]

substance P catabolic process

catabolic process [inference]

peptide catabolic process

neuropeptide catabolic process [inference]

substance P catabolic process

hormone metabolic process

peptide hormone processing [inference]

angiotensin maturation

hormone catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

amyloid-beta metabolic process

cell population proliferation [inference]

cell proliferation in bone marrow

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

reproductive structure development [inference]

gonad development [inference]

male gonad development

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

heart process [inference]

heart contraction

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

maintenance of blood vessel diameter homeostasis by renin-angiotensin

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

maintenance of blood vessel diameter homeostasis by renin-angiotensin

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching

behavior [inference]

feeding behavior [inference]

eating behavior

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure formation involved in morphogenesis [inference]

angiogenesis [inference]

angiogenesis involved in coronary vascular morphogenesis

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching

regeneration [inference]

animal organ regeneration

lung alveolus development

animal organ development [inference]

kidney development

gonad development [inference]

male gonad development

animal organ regeneration

reproductive structure development [inference]

gonad development [inference]

male gonad development

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to lipid [inference]

response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

icosanoid transport [inference]

icosanoid secretion [inference]

arachidonic acid secretion

arachidonate transport [inference]

arachidonic acid secretion

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

icosanoid transport [inference]

icosanoid secretion [inference]

arachidonic acid secretion

arachidonate transport [inference]

arachidonic acid secretion

secretion [inference]

icosanoid secretion [inference]

arachidonic acid secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

negative regulation of calcium ion transport [inference]

negative regulation of calcium ion import

regulation of calcium ion import [inference]

negative regulation of calcium ion import

negative regulation of monoatomic ion transport [inference]

negative regulation of calcium ion transport [inference]

negative regulation of calcium ion import

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of monoatomic ion transport [inference]

negative regulation of calcium ion transport [inference]

negative regulation of calcium ion import

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of monoatomic ion transport [inference]

negative regulation of calcium ion transport [inference]

negative regulation of calcium ion import

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of protein metabolic process [inference]

regulation of angiotensin metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of angiotensin metabolic process

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

regulation of cell population proliferation [inference]

regulation of stem cell proliferation [inference]

regulation of hematopoietic stem cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of gap junction assembly [inference]

negative regulation of gap junction assembly

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of transmembrane transport [inference]

negative regulation of D-glucose transmembrane transport [inference]

negative regulation of D-glucose import across plasma membrane

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of cell junction assembly [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of gap junction assembly [inference]

negative regulation of gap junction assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of blood pressure

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

maintenance of blood vessel diameter homeostasis by renin-angiotensin

positive regulation of blood pressure

positive regulation of systemic arterial blood pressure

regulation of hormone levels [inference]

hormone metabolic process

peptide hormone processing [inference]

angiotensin maturation

hormone catabolic process

regulation of synaptic plasticity

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

maintenance of blood vessel diameter homeostasis by renin-angiotensin

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	ISO
extracellular region	IDA
extracellular region	IBA
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

plasma membrane region [inference]

basal plasma membrane

cell projection membrane [inference]

brush border membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

sperm midpiece

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
actin binding	ISO
endopeptidase activity	ISO
endopeptidase activity	IEA
carboxypeptidase activity
metallocarboxypeptidase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

metalloendopeptidase activity

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

exopeptidase activity

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

peptidyl-dipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

metalloendopeptidase activity

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

exopeptidase activity

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

peptidyl-dipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

bradykinin receptor binding

calmodulin binding

cytoskeletal protein binding [inference]

actin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

chloride ion binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

heterocyclic compound binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

angiotensin-converting enzyme

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
carboxypeptidase activity
hydrolase activity
metal ion binding
metallopeptidase activity
peptidyl-dipeptidase activity
positive regulation of systemic arterial blood pressure
proteolysis
regulation of systemic arterial blood pressure by renin-angiotensin

Displaying 1 entry
InterPro
Peptidase M2, peptidyl-dipeptidase A

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Last updated: April 6, 2026