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activin A receptor, type 1

Summary

Gene Symbol

Acvr1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11477

KEGG Gene ID

PubChem

11477

Alliance of Genome Resources

MGI:87911

Annotation

Keyword

ATP-binding
Glycoprotein
Magnesium
Manganese
Metal-binding
Phosphoprotein
Receptor
Reference proteome
Serine/threonine-protein kinase
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P37172	Activin receptor type I Serine/threonine-protein kinase receptor R1 TGF-B superfamily receptor type I TSK-7L

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 83 in total

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GO Term	Evidence Code	PMID
branching involved in blood vessel morphogenesis	IMP
osteoblast differentiation	ISO
osteoblast differentiation	IEA
urogenital system development	ISO
in utero embryonic development	IMP

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell adhesion involved in heart morphogenesis [inference]

endocardial cushion fusion

cell-cell adhesion [inference]

endocardial cushion fusion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway

transforming growth factor beta receptor superfamily signaling pathway [inference]

cellular process involved in reproduction in multicellular organism [inference]

germ cell development

cellular developmental process [inference]

cell differentiation

osteoblast differentiation

muscle cell differentiation [inference]

smooth muscle cell differentiation

cell fate commitment [inference]

muscle cell fate commitment [inference]

cardiac muscle cell fate commitment

cardiac cell fate commitment [inference]

cardiac muscle cell fate commitment

endocardial cell fate commitment [inference]

endocardial cushion cell fate commitment

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

endocardial cell fate commitment [inference]

endocardial cushion cell fate commitment

cell development [inference]

germ cell development

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development

multicellular organismal reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

germ cell development

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

heart valve morphogenesis [inference]

atrioventricular valve morphogenesis

mitral valve morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis

embryonic morphogenesis [inference]

embryonic heart tube morphogenesis

gastrulation

gastrulation with mouth forming second

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

mesenchyme morphogenesis [inference]

endocardial cushion morphogenesis

cardiac septum morphogenesis [inference]

atrial septum morphogenesis [inference]

atrial septum primum morphogenesis

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation

endocardial cushion formation

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

tissue development [inference]

mesoderm development

cell development [inference]

germ cell development

animal organ development [inference]

heart development

system development [inference]

cellular developmental process [inference]

cell differentiation

osteoblast differentiation

muscle cell differentiation [inference]

smooth muscle cell differentiation

cell fate commitment [inference]

muscle cell fate commitment [inference]

cardiac muscle cell fate commitment

cardiac cell fate commitment [inference]

cardiac muscle cell fate commitment

endocardial cell fate commitment [inference]

endocardial cushion cell fate commitment

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

endocardial cell fate commitment [inference]

endocardial cushion cell fate commitment

cell development [inference]

germ cell development

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus

cellular response to BMP stimulus

response to BMP [inference]

cellular response to BMP stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus

cellular response to BMP stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction

positive regulation of SMAD protein signal transduction

negative regulation of signal transduction

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction

positive regulation of SMAD protein signal transduction

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction

positive regulation of SMAD protein signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction

positive regulation of SMAD protein signal transduction

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction

positive regulation of SMAD protein signal transduction

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

positive regulation of osteoblast differentiation

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction

positive regulation of SMAD protein signal transduction

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

positive regulation of osteoblast differentiation

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

positive regulation of determination of dorsal identity

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

positive regulation of ossification [inference]

positive regulation of bone mineralization

positive regulation of determination of dorsal identity

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction

positive regulation of SMAD protein signal transduction

negative regulation of signal transduction

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction

positive regulation of SMAD protein signal transduction

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction

positive regulation of SMAD protein signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of developmental process

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

regulation of cardiac epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

positive regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

positive regulation of osteoblast differentiation

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

positive regulation of determination of dorsal identity

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway

transforming growth factor beta receptor superfamily signaling pathway [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction

positive regulation of SMAD protein signal transduction

negative regulation of signal transduction

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction

positive regulation of SMAD protein signal transduction

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction

positive regulation of SMAD protein signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

regulation of cardiac epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

positive regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction

positive regulation of SMAD protein signal transduction

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

positive regulation of osteoblast differentiation

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of ossification

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of ossification [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

positive regulation of ossification [inference]

positive regulation of bone mineralization

positive regulation of determination of dorsal identity

regulation of determination of dorsal identity [inference]

positive regulation of determination of dorsal identity

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IDA
plasma membrane	IBA
plasma membrane	IEA
membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

protein kinase complex [inference]

serine/threonine protein kinase complex [inference]

activin receptor complex

cellular anatomical structure [inference]

membrane

plasma membrane

apical part of cell

Displaying entries **1 - 5** of 34 in total

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GO Term	Evidence Code	PMID
protein kinase activity	ISO
protein kinase activity	IEA
protein serine/threonine kinase activity	ISO
protein serine/threonine kinase activity	IEA
transmembrane receptor protein serine/threonine kinase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type I

activin receptor activity [inference]

activin receptor activity, type I

BMP receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type I

activin receptor activity [inference]

activin receptor activity, type I

BMP receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type I

activin receptor activity [inference]

activin receptor activity, type I

BMP receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type I

activin receptor activity [inference]

activin receptor activity, type I

BMP receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type I

activin receptor activity [inference]

activin receptor activity, type I

BMP receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type I

activin receptor activity [inference]

activin receptor activity, type I

BMP receptor activity

binding [inference]

protein binding

growth factor binding

transforming growth factor beta binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding

cytokine binding [inference]

transforming growth factor beta binding

identical protein binding [inference]

protein homodimerization activity

SMAD binding

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

cadherin binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

activin binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type I

activin receptor activity [inference]

activin receptor activity, type I

BMP receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

bone morphogenetic protein receptor

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
nucleotide binding
transmembrane receptor protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase signaling pathway

Displaying **all 8** entries
InterPro
GS domain
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Ser/Thr protein kinase, TGFB receptor
Serine-threonine/tyrosine-protein kinase, catalytic domain
Serine/threonine-protein kinase, active site
Snake toxin-like superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:13374	fibrodysplasia ossificans progressiva	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	79558	RGD:620200
Caenorhabditis elegans	176829	WB:WBGene00000897
Caenorhabditis elegans	174044	WB:WBGene00004860
Homo sapiens	90	HGNC:171

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements