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Guidelines

MIRAGE

cytoglobin

Summary

Gene Symbol

Cygb

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

114886

KEGG Gene ID

PubChem

114886

Alliance of Genome Resources

MGI:2149481

Annotation

Keyword

Cytoplasm
Disulfide bond
Heme
Nucleus
Oxidoreductase
Oxygen transport
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9CX80	Nitric oxygen dioxygenase Nitrite reductase CYGB Pseudoperoxidase CYGB Superoxide dismutase CYGB
Q546K1	Nitrite reductase CYGB Pseudoperoxidase CYGB Superoxide dismutase CYGB

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
response to hypoxia
response to oxidative stress	ISS
response to oxidative stress	ISO
response to oxidative stress	IEA
negative regulation of fibroblast migration	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

nitric oxide catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

removal of superoxide radicals

reactive nitrogen species metabolic process [inference]

nitric oxide metabolic process [inference]

nitric oxide catabolic process

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

response to stimulus [inference]

response to stress [inference]

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

localization [inference]

establishment of localization [inference]

transport [inference]

gas transport [inference]

oxygen transport

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

negative regulation of fibroblast migration

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of collagen biosynthetic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen biosynthetic process

negative regulation of cell activation [inference]

negative regulation of hepatic stellate cell activation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of hepatic stellate cell activation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of collagen biosynthetic process

regulation of collagen biosynthetic process [inference]

negative regulation of collagen biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of collagen biosynthetic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen biosynthetic process

regulation of collagen metabolic process [inference]

negative regulation of collagen metabolic process [inference]

negative regulation of collagen biosynthetic process

regulation of collagen biosynthetic process [inference]

negative regulation of collagen biosynthetic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of collagen biosynthetic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen biosynthetic process

negative regulation of cell activation [inference]

negative regulation of hepatic stellate cell activation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

regulation of cell activation [inference]

negative regulation of cell activation [inference]

negative regulation of hepatic stellate cell activation

regulation of hepatic stellate cell activation [inference]

negative regulation of hepatic stellate cell activation

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

negative regulation of fibroblast migration

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

negative regulation of cell activation [inference]

negative regulation of hepatic stellate cell activation

regulation of hepatic stellate cell activation [inference]

negative regulation of hepatic stellate cell activation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of hepatic stellate cell activation

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nucleus	ISO
nucleus	EXP
nucleus	IDA
nucleus	IEA
cytoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

cell body [inference]

neuronal cell body

supramolecular complex [inference]

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
catalase activity	ISO
peroxidase activity	ISS
peroxidase activity	ISO
superoxide dismutase activity	ISS
superoxide dismutase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on other nitrogenous compounds as donors [inference]

nitrite reductase activity

oxidoreductase activity, acting on a heme group of donors [inference]

nitric oxide dioxygenase activity, heme protein as donor

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

oxidoreductase activity, acting on superoxide radicals as acceptor [inference]

superoxide dismutase activity

binding [inference]

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

carbon monoxide binding

tetrapyrrole binding [inference]

heme binding

antioxidant activity

peroxidase activity

superoxide dismutase activity

molecular carrier activity [inference]

oxygen carrier activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cytoglobin

Functional Category

H: Coenzyme transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
heme binding
iron ion binding
oxidoreductase activity
oxygen binding
oxygen transport

Displaying **all 4** entries
InterPro
Globin, lamprey/hagfish type
Globin-like superfamily
Globin/Protoglobin
Globin

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026