GlyCosmos Portal

Submissions

adrenergic receptor, alpha 1a

Summary

Gene Symbol

Adra1a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11549

KEGG Gene ID

PubChem

11549

Alliance of Genome Resources

MGI:104773

Annotation

Keyword

Cell membrane
Cytoplasm
Disulfide bond
G-protein coupled receptor
Glycoprotein
Nucleus
Palmitate
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q8BUE5	Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor
P97718	Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor
Q8BZV1
Q8BXZ4	Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 53 in total

1

2

3

4

5

…

Next ›

Last »
GO Term	Evidence Code	PMID
regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback	IEA
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure	IMP
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	IMP
positive regulation of heart rate by epinephrine-norepinephrine	IGI
positive regulation of heart rate by epinephrine-norepinephrine	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

neuron-glial cell signaling

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating adrenergic receptor signaling pathway

adrenergic receptor signaling pathway

cell growth [inference]

developmental cell growth [inference]

cell growth involved in cardiac muscle cell development

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

positive regulation of vasoconstriction

vasoconstriction

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

nervous system process [inference]

nervous system process involved in regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

organ growth

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

heart development [inference]

adult heart development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

cell growth involved in cardiac muscle cell development

developmental growth [inference]

organ growth

developmental cell growth [inference]

cell growth involved in cardiac muscle cell development

response to stimulus [inference]

response to external stimulus [inference]

reflex [inference]

pilomotor reflex

response to endogenous stimulus [inference]

response to hormone

response to chemical [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of phospholipase C/protein kinase C signal transduction

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of phospholipase C/protein kinase C signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of phospholipase C/protein kinase C signal transduction

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

positive regulation of synaptic transmission, GABAergic

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

presynaptic modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling

neuron-glial cell signaling

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of phospholipase C/protein kinase C signal transduction

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

positive regulation of action potential

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of phospholipase C/protein kinase C signal transduction

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of phospholipase C/protein kinase C signal transduction

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of vasoconstriction

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of heart rate

positive regulation of heart rate by epinephrine-norepinephrine

positive regulation of cardiac muscle contraction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of multicellular organismal process [inference]

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of phospholipase C/protein kinase C signal transduction

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of phospholipase C/protein kinase C signal transduction

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of phospholipase C/protein kinase C signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating adrenergic receptor signaling pathway

adrenergic receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of phospholipase C/protein kinase C signal transduction

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of phospholipase C/protein kinase C signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of phospholipase C/protein kinase C signal transduction

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

positive regulation of synaptic transmission, GABAergic

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

presynaptic modulation of chemical synaptic transmission

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy

regulation of autophagy [inference]

negative regulation of autophagy

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of phospholipase C/protein kinase C signal transduction

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, GABAergic

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction

regulation of smooth muscle contraction [inference]

positive regulation of smooth muscle contraction

regulation of striated muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cardiac muscle contraction

positive regulation of cardiac muscle contraction

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

regulation of muscle hypertrophy [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of the force of heart contraction [inference]

regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

regulation of heart rate [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

positive regulation of heart rate

positive regulation of heart rate by epinephrine-norepinephrine

negative regulation of heart contraction [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of heart rate

positive regulation of heart rate by epinephrine-norepinephrine

positive regulation of cardiac muscle contraction

regulation of cardiac muscle contraction

positive regulation of cardiac muscle contraction

regulation of vasoconstriction

positive regulation of vasoconstriction

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of heart rate

positive regulation of heart rate by epinephrine-norepinephrine

positive regulation of cardiac muscle contraction

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of vasoconstriction

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of heart rate

positive regulation of heart rate by epinephrine-norepinephrine

positive regulation of cardiac muscle contraction

negative regulation of multicellular organismal process [inference]

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

regulation of action potential [inference]

positive regulation of action potential

regulation of biological quality [inference]

regulation of the force of heart contraction [inference]

regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

regulation of heart rate [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

positive regulation of heart rate

positive regulation of heart rate by epinephrine-norepinephrine

positive regulation of cytosolic calcium ion concentration

regulation of blood pressure

positive regulation of blood pressure [inference]

positive regulation of systemic arterial blood pressure

regulation of membrane potential [inference]

regulation of action potential [inference]

positive regulation of action potential

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

positive regulation of vasoconstriction

vasoconstriction

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

Displaying entries **1 - 5** of 26 in total

1

2

3

4

5

6

Next ›

Last »
GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	ISO
nucleus	IEA
nucleoplasm	ISO
cytoplasm	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

nuclear membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

synaptic membrane [inference]

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

Z disc

cell junction [inference]

synapse [inference]

T-tubule

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IEA
adrenergic receptor activity	IEA
alpha1-adrenergic receptor activity	ISO
alpha1-adrenergic receptor activity	IDA
alpha1-adrenergic receptor activity	IMP

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

protein dimerization activity [inference]

protein heterodimerization activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled amine receptor activity [inference]

adrenergic receptor activity

alpha-adrenergic receptor activity [inference]

alpha1-adrenergic receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	29412	RGD:2055
Caenorhabditis elegans	184572	WB:WBGene00008890
Caenorhabditis elegans	183715	WB:WBGene00016872
Drosophila melanogaster	43484	FB:FBgn0266137
Homo sapiens	148	HGNC:277

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements