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Guidelines

MIRAGE

malic enzyme 2

Summary

Gene Symbol

ME2

Organism

Strigops habroptila (Kakapo)

External Links

NCBI Gene: 115619760
KEGG Gene ID: ["shab:115619760"]
PubChem: 115619760

Annotation

Keyword

Acetylation
Allosteric enzyme
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A672UH75

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
pyruvate metabolic process	IEA
malate metabolic process	IEA
regulation of NADP metabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

dicarboxylic acid metabolic process [inference]

malate metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion	IEA
mitochondrial matrix	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
malate dehydrogenase (decarboxylating) (NAD+) activity	IEA
malate dehydrogenase (decarboxylating) (NADP+) activity	IEA
metal ion binding
NAD binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

malate dehydrogenase activity [inference]

malic enzyme activity [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

malic enzyme

Functional Category

C: Energy production and conversion
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
malate dehydrogenase (decarboxylating) (NADP+) activity
malate metabolic process
malic enzyme activity
metal ion binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 7** entries
InterPro
Aminoacid dehydrogenase-like, N-terminal domain superfamily
Malic enzyme, N-terminal domain superfamily
Malic enzyme, N-terminal domain
Malic enzyme, NAD-binding
Malic enzyme, conserved site
Malic oxidoreductase
NAD(P)-binding domain superfamily

KEGG BRITE Database

Orthology

K00027

Name

malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]

References

225306

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026